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3i06

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==Crystal structure of cruzain covalently bound to a purine nitrile==
==Crystal structure of cruzain covalently bound to a purine nitrile==
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<StructureSection load='3i06' size='340' side='right' caption='[[3i06]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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<StructureSection load='3i06' size='340' side='right'caption='[[3i06]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3i06]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I06 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3i06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I06 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QL2:6-[(3,5-DIFLUOROPHENYL)AMINO]-9-ETHYL-9H-PURINE-2-CARBONITRILE'>QL2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QL2:6-[(3,5-DIFLUOROPHENYL)AMINO]-9-ETHYL-9H-PURINE-2-CARBONITRILE'>QL2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i06 OCA], [http://pdbe.org/3i06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i06 RCSB], [http://www.ebi.ac.uk/pdbsum/3i06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i06 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i06 OCA], [https://pdbe.org/3i06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i06 RCSB], [https://www.ebi.ac.uk/pdbsum/3i06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i06 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cruzipain]]
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[[Category: Large Structures]]
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[[Category: Trycr]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Ferreira, R S]]
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[[Category: Ferreira RS]]
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[[Category: McKerrow, J H]]
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[[Category: McKerrow JH]]
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[[Category: Shoichet, B K]]
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[[Category: Shoichet BK]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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[[Category: Zymogen]]
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Current revision

Crystal structure of cruzain covalently bound to a purine nitrile

PDB ID 3i06

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