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3hk1

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==Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins==
==Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins==
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<StructureSection load='3hk1' size='340' side='right' caption='[[3hk1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3hk1' size='340' side='right'caption='[[3hk1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hk1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HK1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hk1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HK1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B64:4-{[2-(METHOXYCARBONYL)-5-(2-THIENYL)-3-THIENYL]AMINO}-4-OXO-2-BUTENOIC+ACID'>B64</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">adipocyte, Ap2, Fabp4, fatty acid binding protein 4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B64:4-{[2-(METHOXYCARBONYL)-5-(2-THIENYL)-3-THIENYL]AMINO}-4-OXO-2-BUTENOIC+ACID'>B64</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hk1 OCA], [http://pdbe.org/3hk1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hk1 RCSB], [http://www.ebi.ac.uk/pdbsum/3hk1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hk1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hk1 OCA], [https://pdbe.org/3hk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hk1 RCSB], [https://www.ebi.ac.uk/pdbsum/3hk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hk1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>
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[https://www.uniprot.org/uniprot/FABP4_MOUSE FABP4_MOUSE] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<ref>PMID:12077340</ref> <ref>PMID:16574478</ref> <ref>PMID:17516629</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Fatty acid-binding protein|Fatty acid-binding protein]]
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Bernlohr, D A]]
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[[Category: Mus musculus]]
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[[Category: Hellberg, K]]
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[[Category: Bernlohr DA]]
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[[Category: Hertzel, A V]]
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[[Category: Hellberg K]]
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[[Category: Juhlmann, B E]]
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[[Category: Hertzel AV]]
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[[Category: Kruse, A C]]
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[[Category: Juhlmann BE]]
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[[Category: Ohlendorf, D H]]
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[[Category: Kruse AC]]
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[[Category: Reynolds, J M]]
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[[Category: Ohlendorf DH]]
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[[Category: Sanders, M A]]
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[[Category: Reynolds JM]]
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[[Category: Smith, A J]]
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[[Category: Sanders MA]]
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[[Category: Suttles, J]]
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[[Category: Smith AJ]]
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[[Category: Cytoplasm]]
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[[Category: Suttles J]]
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[[Category: Fatty acid binding protein]]
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[[Category: Lipid binding protein]]
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[[Category: Lipid-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Transport]]
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Current revision

Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins

PDB ID 3hk1

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