3bim

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[[Image:3bim.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==
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|PDB= 3bim |SIZE=350|CAPTION= <scene name='initialview01'>3bim</scene>, resolution 2.600&Aring;
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<StructureSection load='3bim' size='340' side='right'caption='[[3bim]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE= BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [https://pdbe.org/3bim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [https://www.ebi.ac.uk/pdbsum/3bim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Disease ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [http://www.ebi.ac.uk/pdbsum/3bim PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB]</span>
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bim_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bim ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The transcriptional corepressors BCOR, SMRT, and NCoR are known to bind competitively to the BCL6 BTB domain despite the fact that BCOR has no detectable sequence similarity to the other two corepressors. We have identified a 17 residue motif from BCOR that binds directly to the BCL6 BTB domain and determined the crystal structure of the complex to a resolution of 2.6 A. Remarkably, the BCOR BCL6 binding domain (BCOR(BBD)) peptide binds in the same BCL6 binding site as the SMRT(BBD) peptide despite the lack of any significant sequence similarity between the two peptides. Mutations of critical BCOR(BBD) residues cause the disruption of the BCL6 corepression activities of BCOR, and a BCOR(BBD) peptide blocks BCL6-mediated transcriptional repression and kills lymphoma cells.
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'''Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide'''
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Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.,Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243<ref>PMID:18280243</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3bim" style="background-color:#fffaf0;"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Microphthalmia, syndromic 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300485 300485]]
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3BIM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ghetu, A F.]]
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[[Category: Ghetu AF]]
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[[Category: Prive, G G.]]
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[[Category: Prive GG]]
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[[Category: activator]]
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[[Category: alternative splicing]]
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[[Category: ank repeat]]
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[[Category: chromatin regulator]]
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[[Category: chromosomal rearrangement]]
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[[Category: disease mutation]]
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[[Category: dna-binding]]
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[[Category: metal-binding]]
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[[Category: nucleus]]
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[[Category: phosphoprotein]]
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[[Category: polymorphism]]
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[[Category: protein-peptide compex]]
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[[Category: proto-oncogene]]
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[[Category: repressor]]
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[[Category: transcription]]
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[[Category: transcription regulation]]
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[[Category: transcription repressor]]
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[[Category: zinc]]
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[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:42 2008''
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Current revision

Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide

PDB ID 3bim

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