3blg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:34, 3 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3blg.gif|left|200px]]
 
-
{{Structure
+
==STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2==
-
|PDB= 3blg |SIZE=350|CAPTION= <scene name='initialview01'>3blg</scene>, resolution 2.56&Aring;
+
<StructureSection load='3blg' size='340' side='right'caption='[[3blg]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=LOP:GLU+89+Is+Involved+In+The+Tanford+Transition+From+The+St+...'>LOP</scene>
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[3blg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BLG FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blg OCA], [https://pdbe.org/3blg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3blg RCSB], [https://www.ebi.ac.uk/pdbsum/3blg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3blg ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blg OCA], [http://www.ebi.ac.uk/pdbsum/3blg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3blg RCSB]</span>
+
[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/3blg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3blg ConSurf].
 +
<div style="clear:both"></div>
-
'''STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2'''
+
==See Also==
-
 
+
*[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The structures of the trigonal crystal form of bovine beta-lactoglobulin variant A at pH 6.2, 7.1, and 8.2 have been determined by X-ray diffraction methods at a resolution of 2.56, 2. 24, and 2.49 A, respectively. The corresponding values for R (Rfree) are 0.192 (0.240), 0.234 (0.279), and 0.232 (0.277). The C and N termini as well as two disulfide bonds are clearly defined in these models. The glutamate side chain of residue 89 is buried at pH 6.2 and becomes exposed at pH 7.1 and 8.2. This conformational change, involving the loop 85-90, provides a structural basis for a variety of pH-dependent chemical, physical, and spectroscopic phenomena, collectively known as the Tanford transition.
+
-
 
+
-
==About this Structure==
+
-
3BLG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLG OCA].
+
-
 
+
-
==Reference==
+
-
Structural basis of the Tanford transition of bovine beta-lactoglobulin., Qin BY, Bewley MC, Creamer LK, Baker HM, Baker EN, Jameson GB, Biochemistry. 1998 Oct 6;37(40):14014-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9760236 9760236]
+
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Baker, E N.]]
+
[[Category: Baker EN]]
-
[[Category: Baker, H M.]]
+
[[Category: Baker HM]]
-
[[Category: Bewley, M C.]]
+
[[Category: Bewley MC]]
-
[[Category: Creamer, L K.]]
+
[[Category: Creamer LK]]
-
[[Category: Jameson, G B.]]
+
[[Category: Jameson GB]]
-
[[Category: Qin, B Y.]]
+
[[Category: Qin BY]]
-
[[Category: beta-lactoglobulin]]
+
-
[[Category: crystal structure]]
+
-
[[Category: loop movement]]
+
-
[[Category: ph-dependent conformation]]
+
-
[[Category: tanford transition]]
+
-
[[Category: transport]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:27:22 2008''
+

Current revision

STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2

PDB ID 3blg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3blg"
Personal tools