6ivd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==TGEV nsp1 mutant - 91-95sg== | |
| + | <StructureSection load='6ivd' size='340' side='right'caption='[[6ivd]], [[Resolution|resolution]] 1.98Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ivd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Transmissible_gastroenteritis_virus Transmissible gastroenteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.975Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivd OCA], [https://pdbe.org/6ivd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivd RCSB], [https://www.ebi.ac.uk/pdbsum/6ivd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/R1A_CVPPU R1A_CVPPU] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SAGC]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Peng | + | [[Category: Large Structures]] |
| - | [[Category: Shen | + | [[Category: Transmissible gastroenteritis virus]] |
| + | [[Category: Peng GQ]] | ||
| + | [[Category: Shen Z]] | ||
Current revision
TGEV nsp1 mutant - 91-95sg
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