3bop

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[[Image:3bop.jpg|left|200px]]
 
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{{Structure
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==Structure of mouse beta-neurexin 2D4==
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|PDB= 3bop |SIZE=350|CAPTION= <scene name='initialview01'>3bop</scene>, resolution 3.000&Aring;
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<StructureSection load='3bop' size='340' side='right'caption='[[3bop]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[3bop]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOP FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE= Nrxn2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bop OCA], [https://pdbe.org/3bop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bop RCSB], [https://www.ebi.ac.uk/pdbsum/3bop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bop ProSAT]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110 LamG]</span>
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</table>
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|RELATEDENTRY=[[3bod|3BOD]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bop OCA], [http://www.ebi.ac.uk/pdbsum/3bop PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bop RCSB]</span>
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[https://www.uniprot.org/uniprot/Q3TQ54_MOUSE Q3TQ54_MOUSE]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/3bop_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bop ConSurf].
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<div style="clear:both"></div>
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'''Structure of mouse beta-neurexin 2D4'''
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==See Also==
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*[[Neurexin|Neurexin]]
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__TOC__
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==Overview==
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</StructureSection>
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Presynaptic neurexins (NRXs) bind to postsynaptic neuroligins (NLs) to form Ca(2+)-dependent complexes that bridge neural synapses. beta-NRXs bind NLs through their LNS domains, which contain a single site of alternative splicing (splice site 4) giving rise to two isoforms: +4 and Delta. We present crystal structures of the Delta isoforms of the LNS domains from beta-NRX1 and beta-NRX2, crystallized in the presence of Ca(2+) ions. The Ca(2+)-binding site is disordered in the beta-NRX2 structure, but the 1.7 A beta-NRX1 structure reveals a single Ca(2+) ion, approximately 12 A from the splice insertion site, with one coordinating ligand donated by a glutamic acid from an adjacent beta-NRX1 molecule. NMR studies of beta-NRX1+4 show that the insertion sequence is unstructured, and remains at least partially disordered in complex with NL. These results raise the possibility that beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding.
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[[Category: Large Structures]]
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==About this Structure==
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3BOP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOP OCA].
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==Reference==
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Crystal Structures of beta-Neurexin 1 and beta-Neurexin 2 Ectodomains and Dynamics of Splice Insertion Sequence 4., Koehnke J, Jin X, Trbovic N, Katsamba PS, Brasch J, Ahlsen G, Scheiffele P, Honig B, Palmer AG 3rd, Shapiro L, Structure. 2008 Mar;16(3):410-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18334216 18334216]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Jin X]]
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[[Category: Jin, X.]]
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[[Category: Koehnke J]]
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[[Category: Koehnke, J.]]
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[[Category: Shapiro L]]
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[[Category: Shapiro, L.]]
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[[Category: beta-neurexin 2d4]]
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[[Category: cell adhesion]]
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[[Category: lectin]]
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[[Category: lns6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:27:57 2008''
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Current revision

Structure of mouse beta-neurexin 2D4

PDB ID 3bop

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