6q5u
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==High resolution electron cryo-microscopy structure of the bacteriophage PR772== | |
| + | <SX load='6q5u' size='340' side='right' viewer='molstar' caption='[[6q5u]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6q5u]] is a 19 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_pr772 Enterobacteria phage pr772]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q5U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Q5U FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6q5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q5u OCA], [http://pdbe.org/6q5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q5u RCSB], [http://www.ebi.ac.uk/pdbsum/6q5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q5u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacteriophage PR772, a member of the Tectiviridae family, has a 70 nm diameter icosahedral protein capsid that encapsulates a lipid membrane, dsDNA, and various internal proteins. An icosahedrally averaged CryoEM reconstruction of the wild-type virion and a localized reconstruction of the vertex region reveal the composition and the structure of the vertex complex along with new protein conformations that play a vital role in maintaining the capsid architecture of the virion. The overall resolution of the virion is 2.75 A, while the resolution of the protein capsid is 2.3 A. The conventional penta-symmetron formed by the capsomeres is replaced by a large vertex complex in the pseudo T = 25 capsid. All the vertices contain the host-recognition protein, P5; two of these vertices show the presence of the receptor-binding protein, P2. The 3D structure of the vertex complex shows interactions with the viral membrane, indicating a possible mechanism for viral infection. | ||
| - | + | Electron cryo-microscopy of bacteriophage PR772 reveals the elusive vertex complex and the capsid architecture.,Reddy HK, Carroni M, Hajdu J, Svenda M Elife. 2019 Sep 12;8. pii: 48496. doi: 10.7554/eLife.48496. PMID:31513011<ref>PMID:31513011</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6q5u" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Enterobacteria phage pr772]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Reddy, H K.Narayana]] | ||
| + | [[Category: Svenda, M]] | ||
| + | [[Category: Beta-propeller]] | ||
| + | [[Category: Double-barrel]] | ||
| + | [[Category: Helix turn helix]] | ||
| + | [[Category: Helix with a kink]] | ||
| + | [[Category: Heteropentamer]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Penton]] | ||
| + | [[Category: Phage]] | ||
| + | [[Category: Tectiviridae]] | ||
| + | [[Category: Virus]] | ||
Current revision
High resolution electron cryo-microscopy structure of the bacteriophage PR772
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