5qhn
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==PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000622a== | ==PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000622a== | ||
| - | <StructureSection load='5qhn' size='340' side='right' caption='[[5qhn]], [[Resolution|resolution]] 1.73Å' scene=''> | + | <StructureSection load='5qhn' size='340' side='right'caption='[[5qhn]], [[Resolution|resolution]] 1.73Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qhn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHN OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5qhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QHN FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GQJ:methyl+(2~{S},4~{R})-1-(furan-2-ylcarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylate'>GQJ</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GQJ:methyl+(2~{S},4~{R})-1-(furan-2-ylcarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylate'>GQJ</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qhn OCA], [https://pdbe.org/5qhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qhn RCSB], [https://www.ebi.ac.uk/pdbsum/5qhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qhn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FA83B_HUMAN FA83B_HUMAN] Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.<ref>PMID:22886302</ref> <ref>PMID:23676467</ref> <ref>PMID:23912460</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Bufton JC]] |
| - | [[Category: | + | [[Category: Bullock AN]] |
| - | [[Category: Douangamath | + | [[Category: Collins P]] |
| - | [[Category: Edwards | + | [[Category: Douangamath A]] |
| - | [[Category: Fox | + | [[Category: Edwards A]] |
| - | [[Category: Krojer | + | [[Category: Fox AE]] |
| - | [[Category: Pinkas | + | [[Category: Krojer T]] |
| - | [[Category: Talon | + | [[Category: Pinkas DM]] |
| - | [[Category: Zhang | + | [[Category: Talon R]] |
| - | [[Category: | + | [[Category: Zhang R]] |
| - | + | [[Category: Von Delft F]] | |
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| - | + | ||
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Current revision
PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000622a
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bufton JC | Bullock AN | Collins P | Douangamath A | Edwards A | Fox AE | Krojer T | Pinkas DM | Talon R | Zhang R | Von Delft F
