5zz9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:10, 22 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of Homer2 EVH1/Drebrin PPXXF complex==
==Crystal structure of Homer2 EVH1/Drebrin PPXXF complex==
-
<StructureSection load='5zz9' size='340' side='right' caption='[[5zz9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='5zz9' size='340' side='right'caption='[[5zz9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5zz9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZZ9 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5zz9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZZ9 FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zz9 OCA], [http://pdbe.org/5zz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/5zz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zz9 ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zz9 OCA], [https://pdbe.org/5zz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zz9 RCSB], [https://www.ebi.ac.uk/pdbsum/5zz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zz9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HOME2_MOUSE HOME2_MOUSE]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. [[http://www.uniprot.org/uniprot/DREB_HUMAN DREB_HUMAN]] Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.<ref>PMID:20215400</ref>
+
[https://www.uniprot.org/uniprot/HOME2_MOUSE HOME2_MOUSE] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Li, J]]
+
[[Category: Homo sapiens]]
-
[[Category: Li, Z]]
+
[[Category: Large Structures]]
-
[[Category: Liu, H]]
+
[[Category: Mus musculus]]
-
[[Category: Liu, W]]
+
[[Category: Li J]]
-
[[Category: Zhang, M]]
+
[[Category: Li Z]]
-
[[Category: Polyproline recognition]]
+
[[Category: Liu H]]
-
[[Category: Protein binding]]
+
[[Category: Liu W]]
-
[[Category: Signaling protein]]
+
[[Category: Zhang M]]

Current revision

Crystal structure of Homer2 EVH1/Drebrin PPXXF complex

PDB ID 5zz9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5zz9"
Personal tools