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3bxk

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[[Image:3bxk.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex==
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|PDB= 3bxk |SIZE=350|CAPTION= <scene name='initialview01'>3bxk</scene>, resolution 2.55&Aring;
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<StructureSection load='3bxk' size='340' side='right'caption='[[3bxk]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+C+149'>AC1</scene>, <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+C+150'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+A+149'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Residue+A+150'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Residue+A+151'>AC5</scene>, <scene name='pdbsite=AC6:Ca+Binding+Site+For+Residue+C+151'>AC6</scene>, <scene name='pdbsite=AC7:Ca+Binding+Site+For+Residue+A+152'>AC7</scene>, <scene name='pdbsite=AC8:Ca+Binding+Site+For+Residue+C+152'>AC8</scene>, <scene name='pdbsite=AC9:So4+Binding+Site+For+Residue+A+153'>AC9</scene>, <scene name='pdbsite=BC1:So4+Binding+Site+For+Residue+C+153'>BC1</scene> and <scene name='pdbsite=BC2:So4+Binding+Site+For+Residue+C+154'>BC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[3bxk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXK FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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|GENE= Calm1, Calm, Cam, Cam1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051 EFh], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5126 FRQ1]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxk OCA], [https://pdbe.org/3bxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxk RCSB], [https://www.ebi.ac.uk/pdbsum/3bxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxk ProSAT]</span></td></tr>
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|RELATEDENTRY=[[3bxl|3BXL]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxk OCA], [http://www.ebi.ac.uk/pdbsum/3bxk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bxk RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/3bxk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bxk ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex'''
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3BXK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXK OCA].
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[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Kooi, C W.Vander.]]
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[[Category: Leahy DJ]]
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[[Category: Leahy, D J.]]
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[[Category: Mori MX]]
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[[Category: Mori, M X.]]
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[[Category: Vander Kooi CW]]
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[[Category: Yue, D T.]]
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[[Category: Yue DT]]
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[[Category: acetylation]]
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[[Category: alternative splicing]]
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[[Category: calcium channel]]
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[[Category: calcium transport]]
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[[Category: calcium-dependent]]
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[[Category: calmodulin]]
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[[Category: facillitation]]
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[[Category: glycoprotein]]
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[[Category: inactivation]]
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[[Category: ion channel]]
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[[Category: ion transport]]
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[[Category: ionic channel]]
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[[Category: iq domain]]
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[[Category: membrane]]
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[[Category: membrane protein]]
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[[Category: methylation]]
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[[Category: phosphoprotein]]
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[[Category: robetta]]
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[[Category: signaling protein]]
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[[Category: simulation]]
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[[Category: transmembrane]]
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[[Category: transport]]
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[[Category: ubl conjugation]]
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[[Category: voltage-gated]]
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[[Category: voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:32 2008''
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Current revision

Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex

PDB ID 3bxk

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