This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3inb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:53, 6 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Structure of the measles virus hemagglutinin bound to the CD46 receptor==
==Structure of the measles virus hemagglutinin bound to the CD46 receptor==
-
<StructureSection load='3inb' size='340' side='right' caption='[[3inb]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+
<StructureSection load='3inb' size='340' side='right'caption='[[3inb]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3inb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mease Mease]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INB FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3inb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Measles_virus_strain_Edmonston Measles virus strain Edmonston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INB FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rkc|2rkc]], [[2zb5|2zb5]], [[2zb6|2zb6]], [[1ckl|1ckl]], [[2o39|2o39]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11235 MEASE]), CD46, MCP, MIC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inb OCA], [https://pdbe.org/3inb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inb RCSB], [https://www.ebi.ac.uk/pdbsum/3inb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inb ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inb OCA], [http://pdbe.org/3inb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3inb RCSB], [http://www.ebi.ac.uk/pdbsum/3inb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3inb ProSAT]</span></td></tr>
+
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/MCP_HUMAN MCP_HUMAN]] Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) [MIM:[http://omim.org/entry/612922 612922]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations.<ref>PMID:14615110</ref> <ref>PMID:14566051</ref> <ref>PMID:16621965</ref> <ref>PMID:16386793</ref> <ref>PMID:20513133</ref>
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE]] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref> [[http://www.uniprot.org/uniprot/MCP_HUMAN MCP_HUMAN]] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.<ref>PMID:10843656</ref> <ref>PMID:12540904</ref>
+
[https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 34: Line 31:
==See Also==
==See Also==
-
*[[Hemagglutinin|Hemagglutinin]]
+
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Mease]]
+
[[Category: Large Structures]]
-
[[Category: Casasnovas, J M]]
+
[[Category: Measles virus strain Edmonston]]
-
[[Category: Celma, M L]]
+
[[Category: Casasnovas JM]]
-
[[Category: Santiago, C]]
+
[[Category: Celma ML]]
-
[[Category: Stehle, T]]
+
[[Category: Santiago C]]
-
[[Category: Beta propeller]]
+
[[Category: Stehle T]]
-
[[Category: Cd46]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Complement control protein]]
+
-
[[Category: Complement pathway]]
+
-
[[Category: Disease mutation]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Envelope protein]]
+
-
[[Category: Fertilization]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Hemagglutinin]]
+
-
[[Category: Host-virus interaction]]
+
-
[[Category: Immune response]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immune system complex]]
+
-
[[Category: Innate immunity]]
+
-
[[Category: Mcp]]
+
-
[[Category: Measles]]
+
-
[[Category: Membrane]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Scr]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Sushi]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Viral protein]]
+
-
[[Category: Viral protein-immune system complex]]
+
-
[[Category: Viral protein. membrane cofactor protein]]
+
-
[[Category: Virion]]
+
-
[[Category: Virus receptor complex]]
+

Current revision

Structure of the measles virus hemagglutinin bound to the CD46 receptor

PDB ID 3inb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3inb"
Personal tools