3c77

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[[Image:3c77.jpg|left|200px]]
 
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{{Structure
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==1.08 A crystal structure of nitrophorin 4 from Rhodnius prolixus containing FE(III) deuteroporphyrin ix complexed with ammonia at ph 7.5==
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|PDB= 3c77 |SIZE=350|CAPTION= <scene name='initialview01'>3c77</scene>, resolution 1.08&Aring;
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<StructureSection load='3c77' size='340' side='right'caption='[[3c77]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Nh3+Binding+Site+For+Residue+X+700'>AC1</scene> and <scene name='pdbsite=AC2:Fde+Binding+Site+For+Residue+X+185'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FDE:FE(III)+DEUTEROPORPHYRIN+IX'>FDE</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene>
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<table><tr><td colspan='2'>[[3c77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2at4 2at4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C77 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.08&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDE:FE(III)+DEUTEROPORPHYRIN+IX'>FDE</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c77 OCA], [https://pdbe.org/3c77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c77 RCSB], [https://www.ebi.ac.uk/pdbsum/3c77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c77 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2at5|2at5]], [[2at6|2at6]], [[3c78|3C78]], [[1x8p|1X8P]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c77 OCA], [http://www.ebi.ac.uk/pdbsum/3c77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3c77 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c77_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c77 ConSurf].
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<div style="clear:both"></div>
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'''1.08 A crystal structure of nitrophorin 4 from Rhodnius prolixus containing FE(III) deuteroporphyrin ix complexed with ammonia at ph 7.5'''
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==See Also==
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*[[Nitrophorin|Nitrophorin]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3C77 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. This structure supersedes the now removed PDB entry 2AT4. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C77 OCA].
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[[Category: Large Structures]]
[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
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[[Category: Single protein]]
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[[Category: Amoia AM]]
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[[Category: Amoia, A M.]]
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[[Category: Montfort WR]]
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[[Category: Montfort, W R.]]
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[[Category: beta barrel]]
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[[Category: fe(iii) deuteroporphyrin ix]]
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[[Category: ferric]]
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[[Category: heme analog]]
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[[Category: iron]]
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[[Category: lipocaln]]
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[[Category: metal-binding]]
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[[Category: secreted]]
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[[Category: transport protein]]
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[[Category: vasoactive]]
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[[Category: vasodilator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:30:57 2008''
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Current revision

1.08 A crystal structure of nitrophorin 4 from Rhodnius prolixus containing FE(III) deuteroporphyrin ix complexed with ammonia at ph 7.5

PDB ID 3c77

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OCA

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