3cfl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (01:40, 21 November 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3cfl.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution==
-
|PDB= 3cfl |SIZE=350|CAPTION= <scene name='initialview01'>3cfl</scene>, resolution 2.25&Aring;
+
<StructureSection load='3cfl' size='340' side='right'caption='[[3cfl]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+2'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+A+687'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+688'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+689'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+690'>AC6</scene>, <scene name='pdbsite=AC7:Fe+Binding+Site+For+Residue+A+691'>AC7</scene>, <scene name='pdbsite=AC8:Co3+Binding+Site+For+Residue+A+692'>AC8</scene>, <scene name='pdbsite=AC9:Zn+Binding+Site+For+Residue+A+3'>AC9</scene>, <scene name='pdbsite=BC1:Zn+Binding+Site+For+Residue+A+4'>BC1</scene>, <scene name='pdbsite=BC2:So4+Binding+Site+For+Residue+A+5'>BC2</scene> and <scene name='pdbsite=BC3:5ch+Binding+Site+For+Residue+A+693'>BC3</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=5CH:5-CHLORO-6&#39;-METHYL-3-[4-(METHYLSULFONYL)PHENYL]-2,3&#39;-BIPYRIDINE'>5CH</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[3cfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFL FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CH:5-CHLORO-6-METHYL-3-[4-(METHYLSULFONYL)PHENYL]-2,3-BIPYRIDINE'>5CH</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfl OCA], [https://pdbe.org/3cfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfl RCSB], [https://www.ebi.ac.uk/pdbsum/3cfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfl ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[2dyx|2dyx]], [[2r9j|2r9j]], [[2px1|2px1]], [[2qz1|2qz1]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfl OCA], [http://www.ebi.ac.uk/pdbsum/3cfl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3cfl RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfl ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution'''
+
==See Also==
-
 
+
*[[Lactoferrin|Lactoferrin]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
3CFL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFL OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Kaur, P.]]
+
[[Category: Kaur P]]
-
[[Category: Mir, R.]]
+
[[Category: Mir R]]
-
[[Category: Sharma, S.]]
+
[[Category: Sharma S]]
-
[[Category: Singh, N.]]
+
[[Category: Singh N]]
-
[[Category: Singh, T P.]]
+
[[Category: Singh TP]]
-
[[Category: Vikram, G.]]
+
[[Category: Vikram G]]
-
[[Category: antibiotic]]
+
-
[[Category: antimicrobial]]
+
-
[[Category: c-lobe]]
+
-
[[Category: complex]]
+
-
[[Category: crystal structure]]
+
-
[[Category: etoricoxib]]
+
-
[[Category: glycoprotein]]
+
-
[[Category: hydrolase]]
+
-
[[Category: ion transport]]
+
-
[[Category: iron]]
+
-
[[Category: iron transport]]
+
-
[[Category: metal binding protein]]
+
-
[[Category: metal-binding]]
+
-
[[Category: protease]]
+
-
[[Category: secreted]]
+
-
[[Category: serine protease]]
+
-
[[Category: transport]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:32:06 2008''
+

Current revision

Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution

PDB ID 3cfl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3cfl"
Personal tools