3ci8

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[[Image:3ci8.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the complex of C-lobe of lactoferrin with vitamin B3 (niacin) at 2.4 A resolution==
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|PDB= 3ci8 |SIZE=350|CAPTION= <scene name='initialview01'>3ci8</scene>, resolution 2.4&Aring;
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<StructureSection load='3ci8' size='340' side='right'caption='[[3ci8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+2'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+A+3'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+4'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+5'>AC5</scene>, <scene name='pdbsite=AC6:Fe+Binding+Site+For+Residue+A+6'>AC6</scene>, <scene name='pdbsite=AC7:Co3+Binding+Site+For+Residue+A+7'>AC7</scene>, <scene name='pdbsite=AC8:Zn+Binding+Site+For+Residue+A+8'>AC8</scene>, <scene name='pdbsite=AC9:Zn+Binding+Site+For+Residue+A+9'>AC9</scene>, <scene name='pdbsite=BC1:So4+Binding+Site+For+Residue+A+10'>BC1</scene> and <scene name='pdbsite=BC2:Nio+Binding+Site+For+Residue+A+11'>BC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NIO:NICOTINIC+ACID'>NIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[3ci8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CI8 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NIO:NICOTINIC+ACID'>NIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00094 TR_FER]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ci8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ci8 OCA], [https://pdbe.org/3ci8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ci8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ci8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ci8 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2dyx|2dyx]], [[2r9j|2r9j]], [[2px1|2px1]], [[2qz1|2qz1]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ci8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ci8 OCA], [http://www.ebi.ac.uk/pdbsum/3ci8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3ci8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/3ci8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ci8 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the complex of C-lobe of lactoferrin with vitamin B3 (niacin) at 2.4 A resolution'''
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==See Also==
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*[[Lactoferrin|Lactoferrin]]
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== References ==
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==About this Structure==
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<references/>
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3CI8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CI8 OCA].
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kaur, P.]]
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[[Category: Kaur P]]
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[[Category: Kushwaha, G S.]]
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[[Category: Kushwaha GS]]
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[[Category: Sharma, S.]]
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[[Category: Sharma S]]
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[[Category: Singh, N.]]
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[[Category: Singh N]]
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[[Category: Singh, T P.]]
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[[Category: Singh TP]]
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[[Category: Vikram, G.]]
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[[Category: Vikram G]]
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[[Category: antibiotic]]
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[[Category: antimicrobial]]
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[[Category: c-lobe]]
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[[Category: complex]]
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[[Category: crystal structure]]
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[[Category: glycoprotein]]
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[[Category: hydrolase]]
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[[Category: ion transport]]
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[[Category: iron]]
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[[Category: iron transport]]
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[[Category: metal binding protein]]
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[[Category: metal-binding]]
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[[Category: niacin]]
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[[Category: protease]]
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[[Category: secreted]]
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[[Category: serine protease]]
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[[Category: transport]]
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[[Category: vitamin b3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:32:22 2008''
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Current revision

Crystal structure of the complex of C-lobe of lactoferrin with vitamin B3 (niacin) at 2.4 A resolution

PDB ID 3ci8

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OCA

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