3kid
From Proteopedia
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==The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator== | ==The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator== | ||
| - | <StructureSection load='3kid' size='340' side='right' caption='[[3kid]], [[Resolution|resolution]] 2.71Å' scene=''> | + | <StructureSection load='3kid' size='340' side='right'caption='[[3kid]], [[Resolution|resolution]] 2.71Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3kid]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3kid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KID FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BS:ETHYL+2-AMINO-1,3-BENZOTHIAZOLE-6-CARBOXYLATE'>2BS</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kid OCA], [https://pdbe.org/3kid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kid RCSB], [https://www.ebi.ac.uk/pdbsum/3kid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kid ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Urokinase|Urokinase]] | + | *[[Urokinase 3D Structures|Urokinase 3D Structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Chen | + | [[Category: Chen LQ]] |
| - | [[Category: Huang | + | [[Category: Huang M-D]] |
| - | [[Category: Huang | + | [[Category: Huang Z-X]] |
| - | [[Category: Jiang | + | [[Category: Jiang L-G]] |
| - | [[Category: Meehan | + | [[Category: Meehan EJ]] |
| - | [[Category: Wang | + | [[Category: Wang JD]] |
| - | [[Category: Yu | + | [[Category: Yu HY]] |
| - | [[Category: Yuan | + | [[Category: Yuan C]] |
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Current revision
The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
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Categories: Homo sapiens | Large Structures | Chen LQ | Huang M-D | Huang Z-X | Jiang L-G | Meehan EJ | Wang JD | Yu HY | Yuan C
