3kas

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==Machupo virus GP1 bound to human transferrin receptor 1==
==Machupo virus GP1 bound to human transferrin receptor 1==
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<StructureSection load='3kas' size='340' side='right' caption='[[3kas]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3kas' size='340' side='right'caption='[[3kas]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Machu Machu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KAS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mammarenavirus_machupoense Mammarenavirus machupoense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KAS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wfo|2wfo]], [[1cx8|1cx8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kas OCA], [http://pdbe.org/3kas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kas RCSB], [http://www.ebi.ac.uk/pdbsum/3kas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kas ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kas OCA], [https://pdbe.org/3kas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kas RCSB], [https://www.ebi.ac.uk/pdbsum/3kas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kas ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TFR1_HUMAN TFR1_HUMAN]] Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.<ref>PMID:3568132</ref>
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[https://www.uniprot.org/uniprot/Q8AZ57_MACHU Q8AZ57_MACHU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/3kas_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/3kas_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Glycoprotein GP|Glycoprotein GP]]
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*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
*[[Transferrin receptor|Transferrin receptor]]
*[[Transferrin receptor|Transferrin receptor]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Machu]]
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[[Category: Large Structures]]
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[[Category: Abraham, J]]
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[[Category: Mammarenavirus machupoense]]
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[[Category: Corbett, K D]]
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[[Category: Abraham J]]
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[[Category: Harrison, S C]]
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[[Category: Corbett KD]]
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[[Category: Arenavirus]]
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[[Category: Harrison SC]]
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[[Category: Cell membrane]]
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[[Category: Disulfide bond]]
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[[Category: Endocytosis]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Machupo virus]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Transferrin receptor 1]]
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[[Category: Transmembrane]]
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[[Category: Viral protein-endocytosis complex]]
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Current revision

Machupo virus GP1 bound to human transferrin receptor 1

PDB ID 3kas

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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