3jxt

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==Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand==
==Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand==
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<StructureSection load='3jxt' size='340' side='right' caption='[[3jxt]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='3jxt' size='340' side='right'caption='[[3jxt]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jxt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JXT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JXT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4DB:(2S)-2-AMINO-4-[5-(DIMETHYLAMINO)-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL]BUTANOIC+ACID'>4DB</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DB:(2S)-2-AMINO-4-[5-(DIMETHYLAMINO)-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL]BUTANOIC+ACID'>4DB</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg3, Dlgh3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxt OCA], [https://pdbe.org/3jxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jxt RCSB], [https://www.ebi.ac.uk/pdbsum/3jxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxt OCA], [http://pdbe.org/3jxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jxt RCSB], [http://www.ebi.ac.uk/pdbsum/3jxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxt ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). [[http://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
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[https://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxt_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Imperiali, B]]
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[[Category: Mus musculus]]
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[[Category: Olivier, N B]]
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[[Category: Rattus norvegicus]]
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[[Category: Sainlos, M]]
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[[Category: Imperiali B]]
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[[Category: 4-dmap]]
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[[Category: Olivier NB]]
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[[Category: Calcium channel]]
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[[Category: Sainlos M]]
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[[Category: Calcium transport]]
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[[Category: Dlg3]]
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[[Category: Fluorogenic probe]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Pdz domain]]
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[[Category: Sap102]]
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[[Category: Signaling protein]]
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[[Category: Solvatochromic flurophore]]
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[[Category: Stargazin]]
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[[Category: Transport]]
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[[Category: Voltage-gated channel]]
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Current revision

Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand

PDB ID 3jxt

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