This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Epithelial discoidin domain-containing receptor
From Proteopedia
(Difference between revisions)
| (11 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='4bkj' size='400' side='right' caption='Human DDR1 kinase domain complex with imatinib and ethylene glycol (PDB code [[4bkj]])' scene='80/805011/Cv/1'> |
== Function == | == Function == | ||
| - | '''Epithelial discoidin domain-containing receptor | + | '''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing [[Receptor tyrosine kinases]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>. |
| + | |||
| + | See also [[Kinase-linked, enzyme-linked and related receptors]]. | ||
== Disease == | == Disease == | ||
| Line 17: | Line 19: | ||
== Structural highlights == | == Structural highlights == | ||
| - | DDR1 contains a discoidin domain. This domain is about 150 amino acid long and is found in many blood coagulation factors. | + | DDR1 contains a discoidin domain. This domain is about 150 amino acid long and is found in many blood coagulation factors. The structure of the <scene name='80/805011/Cv/3'>complex between DDR1 and imatinib</scene> shows hydrogen bonds interactions between the anti-cancer drug and the kinase domain including bonds with the <scene name='80/805011/Cv/4'>kinase allosteric site Asp-Phe-Gly (DFG motif)</scene><ref>PMID:24768818</ref>. Water molecules are shown as red spheres. |
| - | + | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of epithelial discoidin domain-containing receptor | + | ==3D structures of epithelial discoidin domain-containing receptor== |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| + | |||
| + | *Epithelial discoidin domain-containing receptor 1; Domains – discoidin 26-186; ligand-binding 283-385; kinase 543-913 | ||
| + | |||
| + | **[[5bvk]], [[6y23]] – hDDR1 kinase domain – human<br /> | ||
| + | **[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br /> | ||
| + | **[[6few]] – hDDR1 kinase domain + alport syndrome drug<br /> | ||
| + | **[[6fex]], [[6fil]],[[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br /> | ||
| + | **[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]], [[7bcm]], [[7be6]] – hDDR1 kinase domain + inhibitor<br /> | ||
| + | **[[4ag4]] – hDDR1 29-367 domain + antibody<br /> | ||
| + | |||
| + | *Epithelial discoidin domain-containing receptor 2 | ||
| - | [[ | + | **[[2z4f]] – hDDR2 discoidin domain – NMR<br /> |
| - | [[ | + | **[[2wuh]] – hDDR2 discoidin domain + collagen<br /> |
| - | [[ | + | **[[6fer]], [[7aym]] – hDDR2 kinase domain + inhibitor<br /> |
| - | + | }} | |
| - | + | ||
| - | + | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of epithelial discoidin domain-containing receptor
Updated on 19-January-2022
References
- ↑ Roberts ME, Magowan L, Hall IP, Johnson SR. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J. 2011 Jun;37(6):1482-93. doi: 10.1183/09031936.00039710. Epub 2010, Sep 30. PMID:20884741 doi:http://dx.doi.org/10.1183/09031936.00039710
- ↑ 2.0 2.1 Borza CM, Pozzi A. Discoidin domain receptors in disease. Matrix Biol. 2014 Feb;34:185-92. doi: 10.1016/j.matbio.2013.12.002. Epub 2013 Dec, 19. PMID:24361528 doi:http://dx.doi.org/10.1016/j.matbio.2013.12.002
- ↑ Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H, Zheng J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016, Mar 28. PMID:27020590 doi:http://dx.doi.org/10.1007/s13277-016-5021-2
- ↑ Toy KA, Valiathan RR, Nunez F, Kidwell KM, Gonzalez ME, Fridman R, Kleer CG. Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat. 2015 Feb;150(1):9-18. doi: 10.1007/s10549-015-3285-7., Epub 2015 Feb 10. PMID:25667101 doi:http://dx.doi.org/10.1007/s10549-015-3285-7
- ↑ Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818 doi:http://dx.doi.org/10.1016/j.jmb.2014.04.014
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
