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Neurotrophin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='3buk' size='400' side='right' caption='Glycosylated human NT3 homodimer (cyan and green) complex with p75NTR (pink and yellow) (PDB code [[3buk]])' scene='80/805035/Cv/1'> |
== Function == | == Function == | ||
| - | '''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily. | + | '''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor (BDNF) which is a member of the tumor necrosis factor receptor superfamily. |
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== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | + | The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>. | |
| + | *<scene name='80/805035/Cv/3'>Site 1</scene>. | ||
| + | *<scene name='80/805035/Cv/4'>Site 2</scene>. | ||
| + | *<scene name='80/805035/Cv/5'>Site 3</scene>. | ||
</StructureSection> | </StructureSection> | ||
Current revision
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3D structures of neurotrophin
Updated on 01-January-2019
1b8k, 1nt3 – hNT3 – human
3buk – hNT3 + P75NTR
1bnd – hNT3 139-257 + BDNF
1b98 – hNT4 81-210
1b8m, 1hcf – hNT4 81-210 + BDNF
References
- ↑ Facci L, Skaper SD. Culture of rat cerebellar granule neurons and application to identify neuroprotective agents. Methods Mol Biol. 2012;846:23-37. doi: 10.1007/978-1-61779-536-7_3. PMID:22367798 doi:http://dx.doi.org/10.1007/978-1-61779-536-7_3
- ↑ Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163
- ↑ Gong Y, Cao P, Yu HJ, Jiang T. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 2008 Aug 7;454(7205):789-93. Epub 2008 Jul 2. PMID:18596692 doi:10.1038/nature07089
