6h24
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient== | |
| + | <StructureSection load='6h24' size='340' side='right'caption='[[6h24]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6h24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphinx1.76-related_dna Sphinx1.76-related dna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H24 FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1515702 Sphinx1.76-related DNA])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h24 OCA], [http://pdbe.org/6h24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h24 RCSB], [http://www.ebi.ac.uk/pdbsum/6h24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h24 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bovine meat and milk factors (BMMFs) are circular, single-stranded episomal DNAs that have been detected in bovine meat and milk products. BMMFs are thought to have roles in human malignant and degenerative diseases. BMMFs encode a replication initiator protein (Rep) that is actively transcribed and translated in human cells. In this study, a Rep WH1 domain encoded on a BMMF (MSBI1.176) isolated from a multiple sclerosis human brain sample was determined to 1.53 A resolution using X-ray crystallography. The overall structure of the MSBI1.176 WH1 domain was remarkably similar to other Rep structures, despite having a low (28%) amino-acid sequence identity. The MSBI1.176 WH1 domain contained elements common to other Reps, including five alpha-helices, five beta-strands and a hydrophobic pocket. These new findings suggest that the MSBI1.176 Rep might have comparable roles and functions to other known Reps of different origins. | ||
| - | + | Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.,Kilic T, Popov AN, Burk-Korner A, Koromyslova A, Zur Hausen H, Bund T, Hansman GS Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):498-504. doi:, 10.1107/S2059798319003991. Epub 2019 Apr 29. PMID:31063152<ref>PMID:31063152</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6h24" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sphinx1 76-related dna]] | ||
| + | [[Category: Hansman, G S]] | ||
[[Category: Kilic, T]] | [[Category: Kilic, T]] | ||
| + | [[Category: Popov, A N]] | ||
| + | [[Category: Msbi1 176]] | ||
| + | [[Category: Repa]] | ||
| + | [[Category: Replication]] | ||
| + | [[Category: Sclerosis]] | ||
| + | [[Category: Wh1]] | ||
Current revision
X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient
| |||||||||||
Categories: Large Structures | Sphinx1 76-related dna | Hansman, G S | Kilic, T | Popov, A N | Msbi1 176 | Repa | Replication | Sclerosis | Wh1
