6iyc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Recognition of the Amyloid Precursor Protein by Human gamma-secretase== | |
| + | <SX load='6iyc' size='340' side='right' viewer='molstar' caption='[[6iyc]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6iyc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IYC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iyc OCA], [https://pdbe.org/6iyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iyc RCSB], [https://www.ebi.ac.uk/pdbsum/6iyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iyc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cleavage of amyloid precursor protein (APP) by the intramembrane protease gamma-secretase is linked to Alzheimer's disease (AD). We report an atomic structure of human gamma-secretase in complex with a transmembrane (TM) APP fragment at 2.6-angstrom resolution. The TM helix of APP closely interacts with five surrounding TMs of PS1 (the catalytic subunit of gamma-secretase). A hybrid beta sheet, which is formed by a beta strand from APP and two beta strands from PS1, guides gamma-secretase to the scissile peptide bond of APP between its TM and beta strand. Residues at the interface between PS1 and APP are heavily targeted by recurring mutations from AD patients. This structure, together with that of gamma-secretase bound to Notch, reveal contrasting features of substrate binding, which may be applied toward the design of substrate-specific inhibitors. | ||
| - | + | Recognition of the amyloid precursor protein by human gamma-secretase.,Zhou R, Yang G, Guo X, Zhou Q, Lei J, Shi Y Science. 2019 Feb 15;363(6428). pii: science.aaw0930. doi:, 10.1126/science.aaw0930. Epub 2019 Jan 10. PMID:30630874<ref>PMID:30630874</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6iyc" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Gamma secretase|Gamma secretase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Guo X]] | ||
| + | [[Category: Lei J]] | ||
| + | [[Category: Shi Y]] | ||
| + | [[Category: Yang G]] | ||
| + | [[Category: Zhou Q]] | ||
| + | [[Category: Zhou R]] | ||
Current revision
Recognition of the Amyloid Precursor Protein by Human gamma-secretase
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Categories: Homo sapiens | Large Structures | Guo X | Lei J | Shi Y | Yang G | Zhou Q | Zhou R
