3lbd

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[[Image:3lbd.jpg|left|200px]]
 
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{{Structure
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==LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID==
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|PDB= 3lbd |SIZE=350|CAPTION= <scene name='initialview01'>3lbd</scene>, resolution 2.4&Aring;
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<StructureSection load='3lbd' size='340' side='right'caption='[[3lbd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>
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<table><tr><td colspan='2'>[[3lbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LBD FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE= HRARGAMMA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9CR:(9CIS)-RETINOIC+ACID'>9CR</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lbd OCA], [https://pdbe.org/3lbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lbd RCSB], [https://www.ebi.ac.uk/pdbsum/3lbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lbd ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lbd OCA], [http://www.ebi.ac.uk/pdbsum/3lbd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3lbd RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RARG_HUMAN RARG_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/3lbd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lbd ConSurf].
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<div style="clear:both"></div>
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'''LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID'''
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==See Also==
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*[[Retinoic acid receptor 3D structures|Retinoic acid receptor 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3LBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LBD OCA].
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==Reference==
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Conformational adaptation of agonists to the human nuclear receptor RAR gamma., Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D, Nat Struct Biol. 1998 Mar;5(3):199-202. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501913 9501913]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Klaholz, B P.]]
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[[Category: Klaholz BP]]
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[[Category: Mitschler, A.]]
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[[Category: Mitschler A]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Renaud, J P.]]
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[[Category: Renaud J-P]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: active conformation]]
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[[Category: all-trans retinoic acid]]
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[[Category: complex]]
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[[Category: holo form]]
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[[Category: ligand-binding domain]]
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[[Category: ligand-dependent]]
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[[Category: nuclear receptor]]
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[[Category: retinoic acid receptor]]
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[[Category: spine]]
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[[Category: structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:34:15 2008''
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Current revision

LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID

PDB ID 3lbd

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