6ahs

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==Mouse Kallikrein 7 in complex with imidazolinylindole derivative==
==Mouse Kallikrein 7 in complex with imidazolinylindole derivative==
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<StructureSection load='6ahs' size='340' side='right' caption='[[6ahs]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='6ahs' size='340' side='right'caption='[[6ahs]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ahs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AHS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ahs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AHS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9YO:1-[(2-chlorophenyl)sulfonyl]-5-methyl-3-[(4R)-2-methyl-4,5-dihydro-1H-imidazol-4-yl]-1H-indole'>9YO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9YO:1-[(2-chlorophenyl)sulfonyl]-5-methyl-3-[(4R)-2-methyl-4,5-dihydro-1H-imidazol-4-yl]-1H-indole'>9YO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ahs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ahs OCA], [http://pdbe.org/6ahs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ahs RCSB], [http://www.ebi.ac.uk/pdbsum/6ahs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ahs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ahs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ahs OCA], [https://pdbe.org/6ahs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ahs RCSB], [https://www.ebi.ac.uk/pdbsum/6ahs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ahs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLK7_MOUSE KLK7_MOUSE]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
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[https://www.uniprot.org/uniprot/KLK7_MOUSE KLK7_MOUSE] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ahs" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ahs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Stratum corneum chymotryptic enzyme]]
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[[Category: Large Structures]]
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[[Category: Sugawara, H]]
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[[Category: Mus musculus]]
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[[Category: Hydrolase]]
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[[Category: Sugawara H]]
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[[Category: Protease]]
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Current revision

Mouse Kallikrein 7 in complex with imidazolinylindole derivative

PDB ID 6ahs

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