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6n3d

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==Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)==
==Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)==
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<StructureSection load='6n3d' size='340' side='right' caption='[[6n3d]], [[Resolution|resolution]] 1.13&Aring;' scene=''>
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<StructureSection load='6n3d' size='340' side='right'caption='[[6n3d]], [[Resolution|resolution]] 1.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6n3d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6n3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N3D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3d OCA], [http://pdbe.org/6n3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3d RCSB], [http://www.ebi.ac.uk/pdbsum/6n3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3d ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3d OCA], [https://pdbe.org/6n3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n3d RCSB], [https://www.ebi.ac.uk/pdbsum/6n3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HTSF1_HUMAN HTSF1_HUMAN]] Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.<ref>PMID:10393184</ref> <ref>PMID:10454543</ref> <ref>PMID:10913173</ref> <ref>PMID:11420046</ref> <ref>PMID:11780068</ref> <ref>PMID:15905670</ref> <ref>PMID:8849451</ref> <ref>PMID:9765201</ref>
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[https://www.uniprot.org/uniprot/HTSF1_HUMAN HTSF1_HUMAN] Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.<ref>PMID:10393184</ref> <ref>PMID:10454543</ref> <ref>PMID:10913173</ref> <ref>PMID:11420046</ref> <ref>PMID:11780068</ref> <ref>PMID:15905670</ref> <ref>PMID:8849451</ref> <ref>PMID:9765201</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Jenkins, J L]]
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[[Category: Homo sapiens]]
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[[Category: Kielkopf, C L]]
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[[Category: Large Structures]]
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[[Category: Loerch, S]]
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[[Category: Jenkins JL]]
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[[Category: Hiv tat-specific factor 1]]
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[[Category: Kielkopf CL]]
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[[Category: Peptide binding protein]]
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[[Category: Loerch S]]
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[[Category: Pre-mrna splicing factor]]
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[[Category: Rna binding protein]]
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[[Category: Rna splicing factor]]
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[[Category: Tat-sf1]]
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[[Category: U2af homology motif]]
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[[Category: U2af ligand motif]]
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[[Category: Uhm]]
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[[Category: Ulm]]
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Current revision

Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)

PDB ID 6n3d

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