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6dcc

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==Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA==
==Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA==
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<StructureSection load='6dcc' size='340' side='right' caption='[[6dcc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='6dcc' size='340' side='right'caption='[[6dcc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DCC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dcc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DCC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=G5J:'>G5J</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G5J:5-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine'>G5J</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MEPCE, BCDIN3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dcc OCA], [https://pdbe.org/6dcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dcc RCSB], [https://www.ebi.ac.uk/pdbsum/6dcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dcc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dcc OCA], [http://pdbe.org/6dcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dcc RCSB], [http://www.ebi.ac.uk/pdbsum/6dcc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dcc ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MEPCE_HUMAN MEPCE_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.<ref>PMID:17643375</ref>
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[https://www.uniprot.org/uniprot/MEPCE_HUMAN MEPCE_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.<ref>PMID:17643375</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cascio, D]]
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[[Category: Large Structures]]
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[[Category: Eichhorn, C]]
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[[Category: Cascio D]]
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[[Category: Feigon, J]]
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[[Category: Eichhorn C]]
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[[Category: Yang, Y]]
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[[Category: Feigon J]]
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[[Category: 7sk rna]]
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[[Category: Yang Y]]
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[[Category: Mepce]]
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[[Category: Rna methyl transferase]]
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[[Category: Transferase-rna complex]]
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Current revision

Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA

PDB ID 6dcc

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