3kuy

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==DNA Stretching in the Nucleosome Facilitates Alkylation by an Intercalating Antitumor Agent==
==DNA Stretching in the Nucleosome Facilitates Alkylation by an Intercalating Antitumor Agent==
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<StructureSection load='3kuy' size='340' side='right' caption='[[3kuy]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3kuy' size='340' side='right'caption='[[3kuy]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kuy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KUY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kuy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KUY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATV:2-[(2R)-OXIRAN-2-YLMETHYL]-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE'>ATV</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nzd|2nzd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATV:2-[(2R)-OXIRAN-2-YLMETHYL]-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE'>ATV</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuy OCA], [http://pdbe.org/3kuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kuy RCSB], [http://www.ebi.ac.uk/pdbsum/3kuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuy OCA], [https://pdbe.org/3kuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kuy RCSB], [https://www.ebi.ac.uk/pdbsum/3kuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q92130_XENLA Q92130_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).[SAAS:SAAS000558_004_106348] [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Histone|Histone]]
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*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African clawed frog]]
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[[Category: Large Structures]]
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[[Category: Davey, C A]]
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[[Category: Xenopus laevis]]
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[[Category: Wu, B]]
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[[Category: Davey CA]]
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[[Category: Alkylation]]
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[[Category: Wu B]]
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[[Category: Chromatin]]
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[[Category: Chromosomal protein]]
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[[Category: Dna stretching]]
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[[Category: Dna-binding]]
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[[Category: Intercalation]]
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[[Category: Methylation]]
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[[Category: Nucleosome]]
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[[Category: Nucleosome core]]
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[[Category: Nucleus]]
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[[Category: Structural protein-dna complex]]
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Current revision

DNA Stretching in the Nucleosome Facilitates Alkylation by an Intercalating Antitumor Agent

PDB ID 3kuy

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