Alpha-lactalbumin

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<StructureSection load='1hml' size='350' side='right' caption='Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code [[1hml]]).' scene='46/468232/Cv/1' pspeed='8'>
<StructureSection load='1hml' size='350' side='right' caption='Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code [[1hml]]).' scene='46/468232/Cv/1' pspeed='8'>
== Function ==
== Function ==
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'''Alpha-lactalbumin''' (LCA) is the albumin contained in milk and obtained from whey<ref>PMID:10818224</ref>. LCA is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose.
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'''Alpha-lactalbumin''' (LCA) is the albumin contained in milk and obtained from whey<ref>PMID:10818224</ref>. LCA is the regulatory subunit of the '''lactose synthase''' heterodimer which produces lactose by transferring galactose moieties to glucose.
== Relevance ==
== Relevance ==
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*<scene name='46/468232/Cv/4'>Ca coordination site</scene>. Water molecules shown as red spheres.
*<scene name='46/468232/Cv/4'>Ca coordination site</scene>. Water molecules shown as red spheres.
*<scene name='46/468232/Cv/5'>Zn coordination site</scene>.
*<scene name='46/468232/Cv/5'>Zn coordination site</scene>.
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</StructureSection>
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== 3D Structures of α-lactalbumin ==
== 3D Structures of α-lactalbumin ==
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[[Alpha-lactalbumin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*α-lactalbumin
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**[[1alc]] – LCA – baboon
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**[[1hml]], [[1b9o]], [[3b0i]], [[3b0o]] – hLCA –human
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**[[1a4v]] – hLCA Ca-binding domain<br />
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**[[1cb3]] – hLCA residues 1-13 - NMR<br />
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**[[1hfx]] – LCA – guinea pig
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**[[1hfy]], [[3b0k]] – gLCA – goat
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**[[1hmk]], [[1fkq]], [[1fkv]] – gLCA (mutant)
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**[[1f6r]], [[1f6s]], [[2g4n]] – bLCA - bovine
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**[[1hfz]] – bLCA (mutant)
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*α-LCA complexes
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**[[1nf5]] – mLCA + β-1,4-galactosyl transferase + glucose – mouse
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**[[1nhe]] – mLCA + β-1,4-galactosyl transferase + UDP
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**[[1nkh]] – mLCA + β-1,4-galactosyl transferase + UDP + Mn
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**[[1nmm]] – mLCA + β-1,4-galactosyl transferase (mutant)
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**[[1nqi]] - mLCA + β-1,4-galactosyl transferase
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**[[1nwg]] - mLCA + β-1,4-galactosyl transferase + butanoyl-glucosamine
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**[[1o23]] - mLCA + β-1,4-galactosyl transferase + UDP-glucose
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**[[1oqm]] - mLCA + β-1,4-galactosyl transferase + UDP-acetyl-galactosamine
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**[[1pzy]] - mLCA (mutant) + β-1,4-galactosyl transferase + acetyl-glucosamine + UDP + Mn
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**[[1yro]] - mLCA + β-1,4-galactosyl transferase + UDP-galactose + Mn
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**[[1fyc]] - mLCA (mutant) + β-1,4-galactosyl transferase + UDP-galactose + Ca
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**[[2fyd]], [[2fyc]] - mLCA (mutant) + β-1,4-galactosyl transferase + glucose + UDP-acetylgalactosamine + Mn<br />
 
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**[[4l41]] - hLCA + β-1,4-galactosyl transferase (mutant)<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 1hml).

Drag the structure with the mouse to rotate

References

  1. ↑ Permyakov EA, Berliner LJ. alpha-Lactalbumin: structure and function. FEBS Lett. 2000 May 19;473(3):269-74. PMID:10818224

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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