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Calcineurin

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== Function ==
== Function ==
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'''Calcineurin''' (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways.
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'''Calcineurin''' (CN) is a eukaryotic calcium-dependent '''serine/threonine protein phosphatase 2B''' which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways.
For more details see [[Group:MUZIC:Calcineurin]].
For more details see [[Group:MUZIC:Calcineurin]].
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== Structural highlights ==
== Structural highlights ==
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It contains a <scene name='48/489261/Cv/2'>calmodulin-binding catalytic subunit A</scene> and a <scene name='48/489261/Cv/3'>Ca+2-binding regulatory subunit B</scene>. There are <scene name='48/489261/Cv/5'>2 metal ions in CN active site</scene> (molecules of water are shown as red spheres).<ref>PMID:8524402</ref>
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It contains a <scene name='48/489261/Cv/2'>calmodulin-binding catalytic subunit A</scene> and a <scene name='48/489261/Cv/3'>Ca+2-binding regulatory subunit B</scene>. There are <scene name='48/489261/Cv/5'>2 metal ions in CN active site</scene> (molecules of water are shown as red spheres).<ref>PMID:8524402</ref>
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</StructureSection>
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==3D structures of calcineurin==
==3D structures of calcineurin==
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[[Calcineurin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[1tco]] – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine<br />
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[[1aui]] - hCN subunit A, B + Ca + Fe + Zn – human<br />
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[[4il1]] – CN subunit A, B/calmodulin + Ca – rat<br />
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[[1m63]], [[1mf8]] - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn<br />
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[[2p6b]] - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn<br />
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[[3ll8]] - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn<br />
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[[2jog]] - hCN subunit A + NFAT peptide<br />
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[[5c1v]] – hCN subunit A residues 2-347 (mutant) + Fe + Zn<br />
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[[2w73]], [[2jzi]] - hCN subunit A calmodulin-binding domain + calmodulin + Ca<br />
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[[4f0z]] – hCN subunit B + African swine protein virus + Ca<br />
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[[4or9]], [[4ora]], [[4orb]], [[4orc]] – hCN subunit B + serine/threonine protein phosphatase + Ca + Fe + Zn <br />
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[[5b8i]] – hCN subunit B + serine/threonine protein phosphatase + peptidyl-prolyl cis-trans isomerase + Ca + Fe + Zn <br />
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[[5sve]] – hCN subunit B + serine/threonine protein phosphatase + NAFTC1 LXVP peptide + Ca + Fe + Zn <br />
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==References==
==References==

Current revision

Human calcineurin regulatory subunit B (magenta) and catalytic subunit A (cyan) complex with Ca+2 (green), Fe +3 (orange) and Zn+2 (grey) ions, 1aui

Drag the structure with the mouse to rotate

References

  1. ↑ Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al.. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1995 Dec 7;378(6557):641-4. PMID:8524402 doi:http://dx.doi.org/10.1038/378641a0

See Group:MUZIC:Calcineurin.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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