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424d

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[[Image:424d.gif|left|200px]]
 
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{{Structure
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==5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3'==
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|PDB= 424d |SIZE=350|CAPTION= <scene name='initialview01'>424d</scene>, resolution 2.70&Aring;
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<StructureSection load='424d' size='340' side='right'caption='[[424d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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<table><tr><td colspan='2'>[[424d]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=424D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=424D FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=424d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=424d OCA], [https://pdbe.org/424d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=424d RCSB], [https://www.ebi.ac.uk/pdbsum/424d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=424d ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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__TOC__
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=424d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=424d OCA], [http://www.ebi.ac.uk/pdbsum/424d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=424d RCSB]</span>
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</StructureSection>
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}}
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[[Category: Large Structures]]
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[[Category: Frolow F]]
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'''5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3''''
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[[Category: Hegde RS]]
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[[Category: Rabinovich D]]
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[[Category: Rozenberg H]]
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==Overview==
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[[Category: Shakked Z]]
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Transcriptional regulation in papillomaviruses depends on sequence-specific binding of the regulatory protein E2 to several sites in the viral genome. Crystal structures of bovine papillomavirus E2 DNA targets reveal a conformational variant of B-DNA characterized by a roll-induced writhe and helical repeat of 10.5 bp per turn. A comparison between the free and the protein-bound DNA demonstrates that the intrinsic structure of the DNA regions contacted directly by the protein and the deformability of the DNA region that is not contacted by the protein are critical for sequence-specific protein/DNA recognition and hence for gene-regulatory signals in the viral system. We show that the selection of dinucleotide or longer segments with appropriate conformational characteristics, when positioned at correct intervals along the DNA helix, can constitute a structural code for DNA recognition by regulatory proteins. This structural code facilitates the formation of a complementary protein-DNA interface that can be further specified by hydrogen bonds and nonpolar interactions between the protein amino acids and the DNA bases.
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==About this Structure==
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424D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=424D OCA].
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==Reference==
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Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets., Rozenberg H, Rabinovich D, Frolow F, Hegde RS, Shakked Z, Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15194-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9860945 9860945]
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[[Category: Protein complex]]
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[[Category: Frolow, F.]]
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[[Category: Hegde, R S.]]
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[[Category: Rabinovich, D.]]
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[[Category: Rozenberg, H.]]
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[[Category: Shakked, Z.]]
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[[Category: double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:04 2008''
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Current revision

5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3'

PDB ID 424d

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