452d

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[[Image:452d.gif|left|200px]]
 
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{{Structure
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==ACRIDINE BINDING TO DNA==
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|PDB= 452d |SIZE=350|CAPTION= <scene name='initialview01'>452d</scene>, resolution 1.6&Aring;
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<StructureSection load='452d' size='340' side='right'caption='[[452d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=9AD:9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE'>9AD</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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<table><tr><td colspan='2'>[[452d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=452D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=452D FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AD:9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE'>9AD</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=452d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=452d OCA], [https://pdbe.org/452d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=452d RCSB], [https://www.ebi.ac.uk/pdbsum/452d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=452d ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=452d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=452d OCA], [http://www.ebi.ac.uk/pdbsum/452d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=452d RCSB]</span>
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__TOC__
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}}
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</StructureSection>
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[[Category: Large Structures]]
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'''ACRIDINE BINDING TO DNA'''
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[[Category: Cardin CJ]]
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[[Category: Thorpe JH]]
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[[Category: Todd AK]]
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==About this Structure==
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452D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=452D OCA].
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==Reference==
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Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution., Todd AK, Adams A, Thorpe JH, Denny WA, Wakelin LP, Cardin CJ, J Med Chem. 1999 Feb 25;42(4):536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10052960 10052960]
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[[Category: Protein complex]]
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[[Category: Cardin, C J.]]
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[[Category: Thorpe, J H.]]
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[[Category: Todd, A K.]]
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[[Category: groove binding]]
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[[Category: intercalation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:23 2008''
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Current revision

ACRIDINE BINDING TO DNA

PDB ID 452d

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