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3lv6

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==Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP==
==Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP==
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<StructureSection load='3lv6' size='340' side='right' caption='[[3lv6]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='3lv6' size='340' side='right'caption='[[3lv6]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metth Metth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LV6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LV6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.451&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lhw|3lhw]], [[3ltp|3ltp]], [[3lts|3lts]], [[3lty|3lty]], [[3lv5|3lv5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pyrF, MTH_129 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=187420 METTH])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lv6 OCA], [https://pdbe.org/3lv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lv6 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lv6 OCA], [http://pdbe.org/3lv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lv6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
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[https://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
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*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Metth]]
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[[Category: Large Structures]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Fedorov, A A]]
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[[Category: Fedorov AA]]
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[[Category: Fedorov, E V]]
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[[Category: Fedorov EV]]
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[[Category: Gerlt, J A]]
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[[Category: Gerlt JA]]
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[[Category: Wood, B M]]
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[[Category: Wood BM]]
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[[Category: Bmp]]
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[[Category: Decarboxylase]]
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[[Category: Lyase]]
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[[Category: Mutant i218f]]
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[[Category: Pyrimidine biosynthesis]]
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Current revision

Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

PDB ID 3lv6

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