3ly5

<StructureSection load='3ly5' size='340' side='right' caption='[[3ly5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[3ly5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LY5 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDX18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ly5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ly5 OCA], [http://pdbe.org/3ly5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ly5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ly5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ly5 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DDX18_HUMAN DDX18_HUMAN]] Probable RNA-dependent helicase.

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA remodeling is unknown. We present crystal structures of the isolated DEAD-domains of human DDX2A/eIF4A1, DDX2B/eIF4A2, DDX5, DDX10/DBP4, DDX18/myc-regulated DEAD-box protein, DDX20, DDX47, DDX52/ROK1, and DDX53/CAGE, and of the helicase domains of DDX25 and DDX41. Together with prior knowledge this enables a family-wide comparative structural analysis. We propose a general mechanism for opening of the RNA binding site. This analysis also provides insights into the diversity of DExD/H- proteins, with implications for understanding the functions of individual family members.

Comparative structural analysis of human DEAD-box RNA helicases.,Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H PLoS One. 2010 Sep 30;5(9). pii: e12791. PMID:20941364<ref>PMID:20941364</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 3ly5" style="background-color:#fffaf0;"></div>

*[[Helicase|Helicase]]

[[Category: Human]]

[[Category: Arrowsmith, C H]]

[[Category: Berg, S Van Den]]

[[Category: Berglund, H]]

[[Category: Bountra, C]]

[[Category: Collins, R]]

[[Category: Edwards, A M]]

[[Category: Flodin, S]]

[[Category: Flores, A]]

[[Category: Graslund, S]]

[[Category: Hammarstrom, M]]

[[Category: Johansson, A]]

[[Category: Johansson, I]]

[[Category: Kallas, A]]

[[Category: Karlberg, T]]

[[Category: Kotenyova, T]]

[[Category: Kotzsch, A]]

[[Category: Kraulis, P]]

[[Category: Markova, N]]

[[Category: Moche, M]]

[[Category: Nielsen, T K]]

[[Category: Nordlund, P]]

[[Category: Nyman, T]]

[[Category: Persson, C]]

[[Category: Roos, A K]]

[[Category: Structural genomic]]

[[Category: Schuler, H M]]

[[Category: Schutz, P]]

[[Category: Siponen, M I]]

[[Category: Svensson, L]]

[[Category: Thorsell, A G]]

[[Category: Tresaugues, L]]

[[Category: Wahlberg, E]]

[[Category: Weigelt, J]]

[[Category: Welin, M]]

[[Category: Wisniewska, M]]

[[Category: Sgc]]