Carbamoyl phosphate synthetase

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== Function ==
== Function ==
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'''Carbamoyl phosphate synthetase''' (CPS) catalyzes the production of carbamoyl phosphate from ATP, Mg+2, bicarbonate andglutamine. CPS is part of the pyrimidine and arginine biosynthesis as well as the urea cycle in vertebrates. Ornithine is an allosteric effector of CPS.<ref>PMID:5329589</ref> There are 3 forms of CPS:<br />
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'''Carbamoyl phosphate synthetase''' (CPS) catalyzes the production of carbamoyl phosphate from ATP, Mg+2, bicarbonate and glutamine. CPS is part of the pyrimidine and arginine biosynthesis as well as the urea cycle in vertebrates. Ornithine is an allosteric effector of CPS.<ref>PMID:5329589</ref> There are 3 forms of CPS:<br />
* '''CPS I''' participates in the urea cycle. CPS I uses glutamine for NH3 source.<br />
* '''CPS I''' participates in the urea cycle. CPS I uses glutamine for NH3 source.<br />
* '''CPS II''' participates in pyrimidine metabolism<br />
* '''CPS II''' participates in pyrimidine metabolism<br />
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<scene name='49/493669/Cv/13'>K coordination site</scene>.
<scene name='49/493669/Cv/13'>K coordination site</scene>.
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</StructureSection>
 
==3D structures of carbamoyl phosphate synthetase==
==3D structures of carbamoyl phosphate synthetase==
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[[Carbamoyl phosphate synthetase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[1jdb]] - EcCPS + phosphate + glutamine + ADP – ''Escherichia coli''<br />
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[[1a9x]], [[1cs0]] - EcCPS + phosphate + ornithine + ADP<BR />
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[[1c30]], [[1m6v]] - EcCPS (mutant) + phosphate + ornithine + ADP<BR />
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[[1bxr]] - EcCPS + ornithine + AMPPNP<br />
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[[1ce8]] - EcCPS + phosphate + ornithine + inosinic acid + ADP<BR />
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[[1c3o]] - EcCPS (mutant) + phosphate + ornithine + glutamine + ADP<BR />
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[[1kee]] - EcCPS + phosphate + ornithine + acivicin + ADP<BR />
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[[1t36]] - EcCPS (mutant) + phosphate + ornithine + UMP + ADP<BR />
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[[5dot]] – hCPS I – human<br />
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[[2yvq]] – CPS I MGS domain <br />
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[[5dou]] – hCPS I + phosphate + ADP <br />
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli carbamoyl phosphate synthetase large chain (cyan) and small chain (salmon) complex with ADP, phosphate and ornithine, 1a9x

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References

  1. ↑ Kalman SM, Duffield PH, Brzozowski T. Purification and properties of a bacterial carbamyl phosphate synthetase. J Biol Chem. 1966 Apr 25;241(8):1871-7. PMID:5329589
  2. ↑ Thoden JB, Miran SG, Phillips JC, Howard AJ, Raushel FM, Holden HM. Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis. Biochemistry. 1998 Jun 23;37(25):8825-31. PMID:9636022 doi:http://dx.doi.org/10.1021/bi9807761

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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