6c6p

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==Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598==
==Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598==
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<StructureSection load='6c6p' size='340' side='right' caption='[[6c6p]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='6c6p' size='340' side='right'caption='[[6c6p]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c6p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C6P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=EMV:(2E)-N-({3-[([3,3-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine'>EMV</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6c6n|6c6n]], [[6c6r|6c6r]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=EMV:(2E)-N-({3-[([3,3-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine'>EMV</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_monooxygenase Squalene monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.17 1.14.14.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6p OCA], [https://pdbe.org/6c6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c6p RCSB], [https://www.ebi.ac.uk/pdbsum/6c6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6p OCA], [http://pdbe.org/6c6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6p RCSB], [http://www.ebi.ac.uk/pdbsum/6c6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6p ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ERG1_HUMAN ERG1_HUMAN]] Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
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[https://www.uniprot.org/uniprot/ERG1_HUMAN ERG1_HUMAN] Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
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==See Also==
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*[[Epoxidase 3D structures|Epoxidase 3D structures]]
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Squalene monooxygenase]]
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[[Category: Homo sapiens]]
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[[Category: Jin, L]]
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[[Category: Large Structures]]
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[[Category: Padyana, A K]]
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[[Category: Jin L]]
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[[Category: 3-epoxidase]]
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[[Category: Padyana AK]]
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[[Category: Cholesterol synthesis pathway]]
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[[Category: Erg1]]
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[[Category: Fad-dependent monooxygenase]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Sqle]]
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[[Category: Squalene hydroxylase]]
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[[Category: Squalene-2]]
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Current revision

Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598

PDB ID 6c6p

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