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6cwz

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==Crystal structure of apo SUMO E1==
==Crystal structure of apo SUMO E1==
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<StructureSection load='6cwz' size='340' side='right' caption='[[6cwz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='6cwz' size='340' side='right'caption='[[6cwz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cwz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CWZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cwz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CWZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cwy|6cwy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cwz OCA], [http://pdbe.org/6cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cwz RCSB], [http://www.ebi.ac.uk/pdbsum/6cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cwz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cwz OCA], [https://pdbe.org/6cwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cwz RCSB], [https://www.ebi.ac.uk/pdbsum/6cwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cwz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SAE1_HUMAN SAE1_HUMAN]] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:9920803</ref> <ref>PMID:10217437</ref> <ref>PMID:10187858</ref> <ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:15660128</ref> <ref>PMID:20164921</ref> [[http://www.uniprot.org/uniprot/SAE2_HUMAN SAE2_HUMAN]] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:19443651</ref> <ref>PMID:15660128</ref> <ref>PMID:17643372</ref> <ref>PMID:20164921</ref>
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[https://www.uniprot.org/uniprot/SAE1_HUMAN SAE1_HUMAN] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:9920803</ref> <ref>PMID:10217437</ref> <ref>PMID:10187858</ref> <ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:15660128</ref> <ref>PMID:20164921</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6cwz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6cwz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atkison, J H]]
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[[Category: Homo sapiens]]
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[[Category: Lv, Z]]
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[[Category: Large Structures]]
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[[Category: Olsen, S K]]
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[[Category: Atkison JH]]
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[[Category: Williams, K M]]
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[[Category: Lv Z]]
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[[Category: Yuan, L]]
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[[Category: Olsen SK]]
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[[Category: Activity]]
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[[Category: Williams KM]]
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[[Category: Atp binding]]
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[[Category: Yuan L]]
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[[Category: Atp/mg binding]]
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[[Category: Ligase]]
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[[Category: Ligase activity]]
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[[Category: Rossmann-like fold]]
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[[Category: Transferase]]
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[[Category: Ubiquitin activating enzyme]]
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[[Category: Ubiquitin e2]]
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[[Category: Ubiquitin-like fold]]
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Current revision

Crystal structure of apo SUMO E1

PDB ID 6cwz

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