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6hm0

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==Crystal structure of human BRD9 bromodomain in complex with a PROTAC==
==Crystal structure of human BRD9 bromodomain in complex with a PROTAC==
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<StructureSection load='6hm0' size='340' side='right' caption='[[6hm0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='6hm0' size='340' side='right'caption='[[6hm0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hm0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HM0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HM0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBW:(2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide'>GBW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hm0 OCA], [http://pdbe.org/6hm0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hm0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hm0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hm0 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBW:(2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide'>GBW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hm0 OCA], [https://pdbe.org/6hm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hm0 RCSB], [https://www.ebi.ac.uk/pdbsum/6hm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hm0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.
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[https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN] May play a role in chromatin remodeling and regulation of transcription.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hm0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hm0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ciulli, A]]
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[[Category: Homo sapiens]]
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[[Category: Hughes, S J]]
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[[Category: Large Structures]]
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[[Category: Zoppi, V]]
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[[Category: Ciulli A]]
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[[Category: Chromatin regulator]]
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[[Category: Hughes SJ]]
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[[Category: Lysine-acetylated histone binding]]
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[[Category: Zoppi V]]
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[[Category: Protac]]
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[[Category: Transcription]]
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Current revision

Crystal structure of human BRD9 bromodomain in complex with a PROTAC

PDB ID 6hm0

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