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3n39

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Current revision (09:07, 6 September 2023) (edit) (undo)
 
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==Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with NrdI==
==Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with NrdI==
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<StructureSection load='3n39' size='340' side='right' caption='[[3n39]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3n39' size='340' side='right'caption='[[3n39]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n39]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N39 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n39]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N39 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n37|3n37]], [[3n38|3n38]], [[3n3a|3n3a]], [[3n3b|3n3b]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b2676, JW2651, nrdF, ygaD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), nrdI, ygaO, b2674, JW2649 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n39 OCA], [https://pdbe.org/3n39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n39 RCSB], [https://www.ebi.ac.uk/pdbsum/3n39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n39 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n39 OCA], [http://pdbe.org/3n39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n39 RCSB], [http://www.ebi.ac.uk/pdbsum/3n39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n39 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RIR4_ECOLI RIR4_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis. [[http://www.uniprot.org/uniprot/NRDI_ECOLI NRDI_ECOLI]] Probably involved in ribonucleotide reductase function.
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[https://www.uniprot.org/uniprot/RIR4_ECOLI RIR4_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Ribonucleotide reductase|Ribonucleotide reductase]]
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Large Structures]]
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[[Category: Boal, A K]]
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[[Category: Boal AK]]
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[[Category: Cotruvo, J A]]
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[[Category: Cotruvo Jr JA]]
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[[Category: Rosenzweig, A C]]
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[[Category: Rosenzweig AC]]
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[[Category: Stubbe, J]]
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[[Category: Stubbe J]]
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[[Category: Dimanganese cluster]]
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[[Category: Flavoprotein]]
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[[Category: Four-helix bundle]]
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[[Category: Oxidoreductase]]
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[[Category: Ribonucleotide reductase]]
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Current revision

Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with NrdI

PDB ID 3n39

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