3mve

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==Crystal structure of a novel pyruvate decarboxylase==
==Crystal structure of a novel pyruvate decarboxylase==
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<StructureSection load='3mve' size='340' side='right' caption='[[3mve]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3mve' size='340' side='right'caption='[[3mve]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mve]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27562 Atcc 27562]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MVE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MVE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">frsA, VV1_0328 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=672 ATCC 27562])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mve OCA], [http://pdbe.org/3mve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mve RCSB], [http://www.ebi.ac.uk/pdbsum/3mve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mve ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mve OCA], [https://pdbe.org/3mve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mve RCSB], [https://www.ebi.ac.uk/pdbsum/3mve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mve ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/FRSA_VIBVU FRSA_VIBVU] Catalyzes the hydrolysis of esters (PubMed:30951551). In vitro, prefers short chain alkanoate ester as substrate. Displays highest activity towards p-nitrophenyl acetate (pNPA). Has weaker activity towards p-nitrophenyl butyrate (pNPB) (PubMed:30951551).<ref>PMID:30951551</ref>
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The interaction between fermentation-respiration switch (FrsA) protein and glucose-specific enzyme IIA(Glc) increases glucose fermentation under oxygen-limited conditions. We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues required for catalysis as well as the structural basis for the activation by d-IIA(Glc).
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FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.,Lee KJ, Jeong CS, An YJ, Lee HJ, Park SJ, Seok YJ, Kim P, Lee JH, Lee KH, Cha SS Nat Chem Biol. 2011 May 29. PMID:21623357<ref>PMID:21623357</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3mve" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 27562]]
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[[Category: Large Structures]]
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[[Category: An, Y J]]
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[[Category: Vibrio vulnificus]]
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[[Category: Cha, S S]]
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[[Category: An YJ]]
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[[Category: Jeong, C S]]
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[[Category: Cha SS]]
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[[Category: Fermentation/respiration switch protein]]
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[[Category: Jeong CS]]
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[[Category: Frsa]]
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[[Category: Hydrolase activator]]
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[[Category: Lyase]]
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Current revision

Crystal structure of a novel pyruvate decarboxylase

PDB ID 3mve

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