3mqp

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==Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930==
==Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930==
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<StructureSection load='3mqp' size='340' side='right' caption='[[3mqp]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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<StructureSection load='3mqp' size='340' side='right'caption='[[3mqp]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mqp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MQP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mqp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MQP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i1h|3i1h]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2A1, BCL2L5, BFL1, GRS, HBPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mqp OCA], [https://pdbe.org/3mqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mqp RCSB], [https://www.ebi.ac.uk/pdbsum/3mqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mqp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mqp OCA], [http://pdbe.org/3mqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mqp RCSB], [http://www.ebi.ac.uk/pdbsum/3mqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mqp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/APR_HUMAN APR_HUMAN]] Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.<ref>PMID:10807576</ref> <ref>PMID:15705586</ref> <ref>PMID:15694340</ref> <ref>PMID:17374615</ref> <ref>PMID:17389404</ref>
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[https://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[B-cell lymphoma protein|B-cell lymphoma protein]]
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Acton, T B]]
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[[Category: Large Structures]]
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[[Category: Gelinas, C]]
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[[Category: Acton TB]]
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[[Category: Guan, R]]
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[[Category: Gelinas C]]
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[[Category: Montelione, G T]]
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[[Category: Guan R]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: Zhao, L]]
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[[Category: Zhao L]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2 family]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930

PDB ID 3mqp

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