Cathepsin

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CTS B is a cysteine protease. The <scene name='42/421669/Cv/11'>active site</scene> contains a <scene name='42/421669/Cv/13'>C26 residue from the N-terminal domain and H199 residue from the C-terminal domain</scene> (in cyan).<ref>PMID:21598397</ref>
CTS B is a cysteine protease. The <scene name='42/421669/Cv/11'>active site</scene> contains a <scene name='42/421669/Cv/13'>C26 residue from the N-terminal domain and H199 residue from the C-terminal domain</scene> (in cyan).<ref>PMID:21598397</ref>
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</StructureSection>
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== 3D Structures of Cathepsin ==
== 3D Structures of Cathepsin ==
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[[Cathepsin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Procathepsin-A (Lysosomal protective protein)
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-
 
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**[[4ci9]], [[1ivy]], [[4mws]], [[4mwt]] - hCTSB – human<br />
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-
**[[4cia]], [[4cib]] - hCTSB + inhibitor<br />
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* Procathepsin-B
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**[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB <br />
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**[[1mir]] - rPCTSB (mutant) - rat<br />
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**[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br />
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**[[5fpw]] – TbCTSB (mutant)<br />
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* Cathepsin-B mature
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**[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 <br />
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**[[3mor]] - TbCTSB residues 23-340<br />
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**[[3qsd]], [[3s3q]], [[3s3r]] - CTSB (mutant) residues 87-340+ inhibitor – ''Schistosoma mansoni''<br />
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**[[3k9m]] – hMCTSB+stefin A<br />
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**[[3ai8]] – hMCTSB + antibiotic<br />
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**[[2ipp]], [[1huc]] – hMCTSB<br />
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**[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br />
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**[[5mbl]], [[5mbm]] – hMCTSB + darpin <br />
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**[[6ay2]] – hMCTSB + inhibitor <br />
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**[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine<br />
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**[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor<br />
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**[[1ito]], [[1qdq]] – bMCTSB +inhibitor<br />
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**[[1gmy]] - bMCTSB +dipeptidyl nitrile<br />
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**[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat<br />
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**[[1cpj]] - rMCTSB (mutant)<br />
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**[[1cte]] - rMCTSB+pyrimidine inhibitor<br />
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* Cathepsin-C mature or [[Dipeptidyl peptidase]]-I
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**[[2djf]], [[2djg]], [[4oel]], [[4oem]] – hMCTSC + dipeptide<br />
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**[[1jqp]] – rMCTSC <br />
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**[[1k3b]] – hMCTSC <br />
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**[[3pdf]], [[4cdc]], [[4cdd]], [[4cde]], [[4cdf]] – hMCTSC + inhibitor<br />
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* Cathepsin-D mature
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**[[1lyw]], [[1lya]] – hMCTSD <br />
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**[[1lyb]] - hMCTSD+pepstatin<br />
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**[[4obz]], [[4oc6]], [[4od9]] – hMCTSD + non-peptidic inhibitor<br />
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* Cathepsin-E mature
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**[[1tzs]] – hMCTSE+activation peptide from CTSE<br />
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* Cathepsin-F mature
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**[[1m6d]] – hMCTSF+piperidine inhibitor<br />
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* Cathepsin-G mature
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**[[1kyn]] – hMCTSG +naphthalene inhibitor<br />
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**[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br />
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**[[1t32]] - hMCTSG +piperidine inhibitor
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* Cathepsin-H mature
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**[[1nb3]], [[1nb5]] – pMCTSH +stefin A – pig<br />
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**[[8pch]] - pMCTSH <br />
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* Procathepsin-K
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**[[1by8]], [[7pck]] – hPCTSK<br />
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* Cathepsin-K mature
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**[[4n79]], [[5tun]], [[4yva]] – hMCTSK<br />
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**[[5jh3]] – hMCTSK (mutant) <br />
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**[[5t6u]] – mMCTSK<br />
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**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br />
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**[[5qby]], [[5qbv]] – hMCTSK (mutant) + pyrimidine inhibitor<br />
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**[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br />
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**[[3c9e]], [[4n8w]] - hMCTSK + chondroitin-4-sulfate<br />
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**[[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br />
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**[[3kw9]] - hMCTSK +triazine<br />
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**[[1yk8]] - hMCTSK + cyanamide inhibitor<br />
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**[[1yt7]] - hMCTSK + ketoamide inhibitor<br />
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**[[4x6j]] - hMCTSK + benzamide inhibitor<br />
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**[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br />
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**[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br />
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**[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]], [[4dmx]], [[4dmy]] - hMCTSK + pyrrolidine inhibitor<br />
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**[[1snk]] - hMCTSK + norleucine inhibitor<br />
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**[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br />
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**[[1q6k]] - hMCTSK+carbamate inhibitor<br />
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**[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor<br />
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**[[1au2]] - hMCTSK+ propanone inhibitor<br />
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**[[1atk]] – hMCTSK+guanidine inhibitor<br />
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**[[1vsn]], [[5j94]], [[4x6h]], [[4x6i]] - hMCTSK+ inhibitor<br />
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**[[2ato]] – hMCTSK+myocrisin<br />
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**[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br />
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**[[1u9w]] - hMCTSK+imidazole inhibitor<br />
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**[[5tdi]], [[4yv8]] – hMCTSK + odanacatib<br />
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**[[5tdi]] – hMCTSK + lichostatinal<br />
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**[[5ja7]] – hMCTSK (mutant) + effector<br />
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**[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br />
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**[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br />
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*Procathepsin-L
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**[[1cjl]], [[1cs8]] - hPCTS-L (mutant)<br />
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**[[3qj3]] - PCTS-L (mutant) – ''Tenebrio molitor''<br />
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* Cathepsin-L mature
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**[[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br />
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**[[2p86]] – TbMCTSL +K11002<br />
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**[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br />
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**[[4axl]] – hMCTSL catalytic domain<br />
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**[[4axm]] – hMCTSL catalytic domain + inhibitor<br />
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**[[1mhw]] – hMCTSL +tripeptide<br />
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**[[1icf]] – hMCTSL +MHC class II fragment<br />
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* Procathepsin-L1
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**[[2o6x]] – hPCTSL1 (mutant) – ''Fasciola hepatica''<br />
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* Cathepsin-L1 mature
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**[[4axl]] – hMCTSL1 catalytic domain<br />
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**[[3iv2]], [[5i4h]] – hMCTSL1 (mutant) <br />
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**[[3k24]] - hMCTSL1 (mutant) +tripeptide<br />
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**[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br />
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**[[2xu1]], [[2xu3]], [[2xu4]], [[2xu5]], [[2yj2]], [[2yj8]], [[2yj9]], [[2yjb]], [[2yjc]] - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor<br />
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**[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br />
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**[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br />
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**[[5mqy]] – hMCTSL1 + pyrimidine inhibitor<br />
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**[[3kse]] – hMCTSL1 (mutant)+stefin<br />
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**[[4axm]], [[5mae]], [[5maj]], [[5f02]], [[3bc3]], [[3of9]] – hMCTSL1 catalytic domain + inhibitor<br />
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* Cathepsin-L2 mature
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**[[3h6s]] – hMCTSL2+clitocypin<br />
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**[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor<br />
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**[[3kfq]] - hMCTSL2 (mutant)+stefin
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* Procathepsin-S
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**[[2c0y]] – hPCTSS (mutant)<br />
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* Cathepsin-S mature
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+
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**[[3n3g]], [[3n4c]] - hMCTSS+ pyrimidine inhibitor<br />
+
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**[[3ovx]] - hMCTSS+ aldehyde inhibitor<br />
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**[[3ovz]] - hMCTSS+ ketoamide inhibitor<br />
+
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**[[5qc4]] – hMCTSS (mutant)+ thioether acetamide<br />
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**[[3iej]], [[5qcf]], [[5qce]], [[5qcd]], [[5qcc]], [[5qcg]], [[5qch]], [[5qci]] - hMCTSS (mutant)+pyrazole inhibitor<br />
+
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**[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br />
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**[[2r9m]], [[2r9n]], [[2r9o]], [[5qcj]] – hMCTSS+piperidine inhibitor<br />
+
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**[[5qbu]], [[5qbw]], [[5qbx]], [[5qbz]], [[5qc0]], [[5qc1]], [[5qc2]], [[5qc3]], [[5qc5]], [[5qc6]], [[5qc7]], [[5qc8]], [[5qc9]], [[5qca]], [[5qcb]] – hMCTSS (mutant) + piperidine inhibitor<br />
+
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**[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br />
+
-
**[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]], [[4p6e]], [[4p6g]] – hMCTSS+inhibitor<br />
+
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**[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br />
+
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**[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br />
+
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**[[1glo]] - hMCTSS (mutant)<br />
+
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**[[4bs5]], [[4mzo]], [[4mzs]] - mMCTSS+ pyrrolidine inhibitor<br />
+
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**[[4bsq]] - mMCTSS+ morpholine inhibitor<br />
+
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**[[4bpv]], [[4bqv]], [[4bs6]] - mMCTSS +nitrile inhibitor<br />
+
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* Procathepsin-X
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**[[1deu]] - hPCTSX<br />
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* Cathepsin-X mature
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**[[1ef7]] – hMCTSX<br />
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}}
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+

Current revision

human cathepsin B complex with inhibitor 3ai8

Drag the structure with the mouse to rotate


References

  1. ↑ Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9. PMID:15751268
  2. ↑ Mirkovic B, Renko M, Turk S, Sosic I, Jevnikar Z, Obermajer N, Turk D, Gobec S, Kos J. Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds. ChemMedChem. 2011 May 20. doi: 10.1002/cmdc.201100098. PMID:21598397 doi:10.1002/cmdc.201100098

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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