6jb7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6jb7 is ON HOLD Authors: Lee, J.-G., Youn, H.-S., Lee, Y., An, J.Y., Park, K.R., Kang, J.Y., Mun, S.A., Park, J., Park, T., Jin, M.W., Yang, J., Eom...)
Current revision (10:37, 27 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6jb7 is ON HOLD
+
==Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution==
 +
<StructureSection load='6jb7' size='340' side='right'caption='[[6jb7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6jb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JB7 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jb7 OCA], [https://pdbe.org/6jb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jb7 RCSB], [https://www.ebi.ac.uk/pdbsum/6jb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jb7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UBE2K_HUMAN UBE2K_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.<ref>PMID:8702625</ref> <ref>PMID:10634809</ref> <ref>PMID:10675012</ref> <ref>PMID:16714285</ref> <ref>PMID:16868077</ref> <ref>PMID:17873885</ref> <ref>PMID:20061386</ref> <ref>PMID:19906396</ref>
-
Authors: Lee, J.-G., Youn, H.-S., Lee, Y., An, J.Y., Park, K.R., Kang, J.Y., Mun, S.A., Park, J., Park, T., Jin, M.W., Yang, J., Eom, S.H.
+
==See Also==
-
 
+
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-
Description: Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution
+
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
-
[[Category: Unreleased Structures]]
+
== References ==
-
[[Category: An, J.Y]]
+
<references/>
-
[[Category: Youn, H.-S]]
+
__TOC__
-
[[Category: Park, T]]
+
</StructureSection>
-
[[Category: Park, K.R]]
+
[[Category: Homo sapiens]]
-
[[Category: Mun, S.A]]
+
[[Category: Large Structures]]
-
[[Category: Kang, J.Y]]
+
[[Category: An JY]]
-
[[Category: Yang, J]]
+
[[Category: Eom SH]]
-
[[Category: Park, J]]
+
[[Category: Jin MW]]
-
[[Category: Lee, J.-G]]
+
[[Category: Kang JY]]
-
[[Category: Lee, Y]]
+
[[Category: Lee J-G]]
-
[[Category: Eom, S.H]]
+
[[Category: Lee Y]]
-
[[Category: Jin, M.W]]
+
[[Category: Mun SA]]
 +
[[Category: Park J]]
 +
[[Category: Park KR]]
 +
[[Category: Park T]]
 +
[[Category: Yang J]]
 +
[[Category: Youn H-S]]

Current revision

Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution

PDB ID 6jb7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6jb7"
Personal tools