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6dym

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==C-terminal condensation domain of Ebony==
==C-terminal condensation domain of Ebony==
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<StructureSection load='6dym' size='340' side='right' caption='[[6dym]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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<StructureSection load='6dym' size='340' side='right'caption='[[6dym]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dym]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DYM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DYM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dym OCA], [http://pdbe.org/6dym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dym RCSB], [http://www.ebi.ac.uk/pdbsum/6dym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dym ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dym OCA], [https://pdbe.org/6dym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dym RCSB], [https://www.ebi.ac.uk/pdbsum/6dym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dym ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EBO_DROME EBO_DROME] Nonribosomal peptide synthase which is required for the regulation of histamine and dopamine levels in various tissues through their condensation with beta-alanine (PubMed:12900414, PubMed:19715698, PubMed:25229196, PubMed:30705105). In epithelial glial cells, plays an essential role in the inactivation of histamine, the main neurotransmitter in the optical nerve system, by catalyzing the conversion of histamine into carcinine (PubMed:5782111, PubMed:12486147, PubMed:12900414, PubMed:25229196, PubMed:30705105). In the cuticle, catalyzes the condensation of beta-alanine with dopamine to form beta-alanyl-dopamine (NBAD), a metabolite involved in the pigmentation and sclerotization of the insect cuticle (PubMed:8580497, PubMed:11934851). Also, regulates the cuticular hydrocarbon composition in females (PubMed:31118901). Acts downstream of the body clock to regulate circadian behavioral rhythms (PubMed:17678856). Can also condense beta-alanine with biogenic amines tyramine, octopamine, and serotonin in vitro (PubMed:12900414, PubMed:19715698).<ref>PMID:11934851</ref> <ref>PMID:12486147</ref> <ref>PMID:12900414</ref> <ref>PMID:17678856</ref> <ref>PMID:19715698</ref> <ref>PMID:25229196</ref> <ref>PMID:30705105</ref> <ref>PMID:31118901</ref> <ref>PMID:5782111</ref> <ref>PMID:8580497</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cryle, M J]]
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[[Category: Drosophila melanogaster]]
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[[Category: Hansen, M H]]
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[[Category: Large Structures]]
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[[Category: Izore, T]]
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[[Category: Cryle MJ]]
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[[Category: Jackson, C J]]
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[[Category: Hansen MH]]
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[[Category: Kaczmarski, J A]]
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[[Category: Izore T]]
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[[Category: Tailhades, J]]
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[[Category: Jackson CJ]]
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[[Category: Biosynthetic protein]]
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[[Category: Kaczmarski JA]]
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[[Category: Condensation domain]]
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[[Category: Tailhades J]]
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[[Category: Nrp]]
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[[Category: Peptide-bond formation]]
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Current revision

C-terminal condensation domain of Ebony

PDB ID 6dym

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