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3o99

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==Crystal Structure of wild-type HIV-1 Protease in complex with kd13==
==Crystal Structure of wild-type HIV-1 Protease in complex with kd13==
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<StructureSection load='3o99' size='340' side='right' caption='[[3o99]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='3o99' size='340' side='right'caption='[[3o99]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o99]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O99 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o99]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O99 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K13:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL+[(1S,2R)-3-{[(4-AMINOPHENYL)SULFONYL][(2S)-2-METHYLBUTYL]AMINO}-1-BENZYL-2-HYDROXYPROPYL]CARBAMATE'>K13</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o9a|3o9a]], [[3o9b|3o9b]], [[3o9c|3o9c]], [[3o9d|3o9d]], [[3o9e|3o9e]], [[3o9f|3o9f]], [[3o9g|3o9g]], [[3o9h|3o9h]], [[3o9i|3o9i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K13:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL+[(1S,2R)-3-{[(4-AMINOPHENYL)SULFONYL][(2S)-2-METHYLBUTYL]AMINO}-1-BENZYL-2-HYDROXYPROPYL]CARBAMATE'>K13</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol, pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o99 OCA], [https://pdbe.org/3o99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o99 RCSB], [https://www.ebi.ac.uk/pdbsum/3o99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o99 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o99 OCA], [http://pdbe.org/3o99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o99 RCSB], [http://www.ebi.ac.uk/pdbsum/3o99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o99 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q90K99_9HIV1 Q90K99_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Nalam, M N.L]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Schiffer, C A]]
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[[Category: Large Structures]]
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[[Category: Aid]]
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[[Category: Nalam MNL]]
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[[Category: Aspartyl protease]]
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[[Category: Schiffer CA]]
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[[Category: Drug design]]
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[[Category: Drug resistance]]
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[[Category: Hiv-1 protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease inhibitor]]
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Current revision

Crystal Structure of wild-type HIV-1 Protease in complex with kd13

PDB ID 3o99

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