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2ens
From Proteopedia
(Difference between revisions)
(New page: 200px {{Structure |PDB= 2ens |SIZE=350|CAPTION= <scene name='initialview01'>2ens</scene> |SITE= |LIGAND= |ACTIVITY= |GENE= AGER ([http://www.ncbi.nlm.nih.gov/T...) |
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| - | [[Image:2ens.jpg|left|200px]] | ||
| - | + | ==Solution structure of the third ig-like domain from human Advanced glycosylation end product-specific receptor== | |
| - | + | <StructureSection load='2ens' size='340' side='right'caption='[[2ens]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ens]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ENS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGER ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | | | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ens FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ens OCA], [https://pdbe.org/2ens PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ens RCSB], [https://www.ebi.ac.uk/pdbsum/2ens PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ens ProSAT], [https://www.topsan.org/Proteins/RSGI/2ens TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/2ens_consurf.spt"</scriptWhenChecked> | |
| - | == | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ens ConSurf]. |
| - | [[Category: Hayashi, F | + | <div style="clear:both"></div> |
| - | [[Category: Kurosaki, C | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Wakabayashi, M | + | __TOC__ |
| - | [[Category: Yokoyama, S | + | </StructureSection> |
| - | [[Category: Yoshida, M | + | [[Category: Human]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hayashi, F]] |
| - | [[Category: | + | [[Category: Kurosaki, C]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Wakabayashi, M]] |
| - | [[Category: | + | [[Category: Yokoyama, S]] |
| - | + | [[Category: Yoshida, M]] | |
| - | + | [[Category: Beta-sandwich]] | |
| - | + | [[Category: C2-set]] | |
| - | + | [[Category: National project on protein structural and functional analyse]] | |
| + | [[Category: Nppsfa]] | ||
| + | [[Category: Rsgi]] | ||
| + | [[Category: Signaling protein]] | ||
Current revision
Solution structure of the third ig-like domain from human Advanced glycosylation end product-specific receptor
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