Pseudouridine synthase

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<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
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__TOC__
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==Function==
[[Pseudouridine]] is an abundant modified nucleoside found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the bond between base and ribose in uridine. There are two major types of enzymes that catalyze this reaction:
[[Pseudouridine]] is an abundant modified nucleoside found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the bond between base and ribose in uridine. There are two major types of enzymes that catalyze this reaction:
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== Structural highlights ==
== Structural highlights ==
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The conversion of uridine to pseudouridine is accompanied by a conformational change of pseudouridine synthase<ref>PMID:14990747</ref>. <scene name='46/465439/Cv/3'>tRNA pseudouridine synthase binding with pseudouridine monophosphate</scene> ([[1ze2]]).
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The conversion of uridine to pseudouridine is accompanied by a conformational change of pseudouridine synthase<ref>PMID:14990747</ref>. <scene name='46/465439/Cv/4'>tRNA pseudouridine synthase binding with pseudouridine monophosphate</scene> ([[1ze2]]).
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</StructureSection>
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== 3D Structures of pseudouridine synthase ==
== 3D Structures of pseudouridine synthase ==
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[[Pseudouridine synthase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Pseudouridine synthase
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**[[1dj0]] – EcPUS I – ''Escherichia coli''<br />
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**[[1ze1]] – TmPUS B – ''Thermotoga maritima''<br />
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**[[1ksk]], [[1ksl]] – EcPUS RsuA <br />
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**[[1vio]] - PUS RsuA – ''Haemophilus influenzae''<br />
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**[[1xpi]] - EcPUS RluC catalytic domain<br />
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**[[1v9k]] - EcPUS RluC C-terminal domain (mutant) <br />
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**[[2ist]] - EcPUS RluD <br />
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**[[1prz]], [[1qyu]], [[1v9f]] - EcPUS RluD catalytic domain<br />
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**[[2olw]] - EcPUS RluE<br />
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**[[2oml]] - EcPUS RluE catalytic domain<br />
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**[[2gml]] - EcPUS RluF catalytic domain<br />
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**[[4iqm]], [[4its]], [[4j37]], [[4nz6]] - hPUS Pus1 catalytic domain - human<br />
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**[[4nz7]] - hPUS Pus1 catalytic domain (mutant)<br />
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**[[1vs3]] – PUS TruA – ''Thermus thermophilus''<br />
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**[[1sgv]] – PUS TruB – ''Mycobacterium tuberculosis''<br />
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**[[1si7]], [[1szw]], [[1sb7]] - EcPUS TruD<br />
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* Pseudouridine synthase complex with RNA
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**[[1k8w]] – EcPUS B + stem-loop RNA <br />
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**[[1zl3]] - EcPUS B (mutant) + stem-loop RNA<br />
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**[[2i82]] – EcPUS RluA + RNA<br />
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**[[3dh3]] - EcPUS RluF + RNA<br />
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**[[2nqp]], [[2nr0]], [[2nre]] – EcPUS TruA + Leu-tRNA<br />
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**[[3hjw]], [[3lwo]], [[3lwp]], [[3lwq]], [[3lwr]], [[3lwv]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA – ''Pyrococcus furiosus''<br />
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**[[3mqk]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<br />
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**[[3hjy]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA<br />
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**[[1ze2]] - TmPUS B + RNA<br />
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**[[2ab4]] - TmPUS B (mutant) + RNA<br />
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**[[1r3e]], [[1r3f]] - EcPUS B + RNA<br />
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* Probable pseudouridine synthase
 
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**[[2apo]] – PPUS + ribosome biogenesis protein Nop10 – ''Methanocaldococcus jannaschii''<br />
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[[Category:Topic Page]]
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**[[2ey4]] - PfPPUS Cbf5 + ribosome biogenesis protein Nop10 + small nucleolar RNP <br />
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**[[2hvy]], [[3hax]] - PfPPUS B + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA<br />
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**[[2rfk]] - PfPUS B + ribosome biogenesis protein Nop10 + small nucleolar RNP + RNA<br />
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**[[3hay]] - PfPPUS B + ribosome biogenesis protein Nop10 + ribosomal protein L7 + small nucleolar RNP + RNA<br />
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**[[2aus]] – PPUS B + ribosome biogenesis protein Nop10 – ''Pyrococcus abyssi''<br />
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**[[1z2z]] – PPUS D – Methanosarcina mazei<br />
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}}
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Current revision

tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate 1ze2

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