2eq7

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(New page: 200px {{Structure |PDB= 2eq7 |SIZE=350|CAPTION= <scene name='initialview01'>2eq7</scene>, resolution 1.80&Aring; |SITE= <scene name='pdbsite=AC1:Fad+Binding+Site+...)
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[[Image:2eq7.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of lipoamide dehydrogenase from thermus thermophilus HB8 with psbdo==
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|PDB= 2eq7 |SIZE=350|CAPTION= <scene name='initialview01'>2eq7</scene>, resolution 1.80&Aring;
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<StructureSection load='2eq7' size='340' side='right'caption='[[2eq7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Fad+Binding+Site+For+Residue+A+2482'>AC1</scene>, <scene name='pdbsite=AC2:Nad+Binding+Site+For+Residue+A+2483'>AC2</scene>, <scene name='pdbsite=AC3:Fad+Binding+Site+For+Residue+B+1482'>AC3</scene> and <scene name='pdbsite=AC4:Nad+Binding+Site+For+Residue+B+1483'>AC4</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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<table><tr><td colspan='2'>[[2eq7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQ7 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyl_dehydrogenase Dihydrolipoyl dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.4 1.8.1.4] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= TTHA0287 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02852 Pyr_redox_dim], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00070 Pyr_redox], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK06327 PRK06327], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK07208 PRK07208], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02817 E3_binding]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eq7 OCA], [https://pdbe.org/2eq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eq7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eq7 TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eq7 OCA], [http://www.ebi.ac.uk/pdbsum/2eq7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eq7 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q5SLK5_THET8 Q5SLK5_THET8] The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity).[RuleBase:RU361138]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/2eq7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eq7 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of lipoamide dehydrogenase from thermus thermophilus HB8 with psbdo'''
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==See Also==
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*[[Dihydrolipoamide dehydrogenase|Dihydrolipoamide dehydrogenase]]
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*[[2-oxoglutarate dehydrogenase 3D structures|2-oxoglutarate dehydrogenase 3D structures]]
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==About this Structure==
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__TOC__
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2EQ7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQ7 OCA].
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</StructureSection>
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[[Category: Dihydrolipoyl dehydrogenase]]
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[[Category: Citric Acid Cycle]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Kamiya, N.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Nakai, T.]]
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[[Category: Kamiya N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nakai T]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: oxidoreductase]]
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[[Category: protein-protein complex]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:57:05 2008''
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Current revision

Crystal structure of lipoamide dehydrogenase from thermus thermophilus HB8 with psbdo

PDB ID 2eq7

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