Tuba

From Proteopedia

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(New page: <StructureSection load='4cc2' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for your page '''Tuba'''. Click above on '''edit this page''' t...)
Current revision (08:21, 19 February 2019) (edit) (undo)
 
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<StructureSection load='4cc2' size='340' side='right' caption='Human Tuba 6th SH3 domain (grey) complex with N-WASP peptide (green), glycerol and Cl- ion (PDB code [[4cc2]])' scene=''>
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<StructureSection load='4cc2' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page '''Tuba'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
== Function ==
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'''Tuba''' or '''dynamin-binding protein''' is a scaffold protein found in brain synapses which brings together dynamin and actin regulatory proteins. The N-terminal SH3 domains bind dynamin and the C-terminal SH3 domain binds actin regulatory proteins<ref>PMID:14506234</ref>.
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For more details see [[Schubert lab: bacterial InIC disrupts human Tuba complexes]].
== Disease ==
== Disease ==
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== Relevance ==
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Tuba deficiency causes and abnormal renal ciliary and morphogenetic phenotype. Tuba has a critical role in ciliogenesis and nephrogenesis by regulating Cdc42 activity<ref>PMID:26895965</ref>.
== Structural highlights ==
== Structural highlights ==
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Tuba contains 6 SH3 domains. The C-terminal 6th domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues<ref>PMID:24332715</ref>.
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Tuba contains 6 SH3 domains. The C-terminal 6th SH3 domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues<ref>PMID:24332715</ref>.
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</StructureSection>
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==Tuba 3D structures==
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See [[Tuba 3D structures]]
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== References ==
== References ==
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[[Category:Topic Page]]

Current revision

Human Tuba 6th SH3 domain (grey) complex with N-WASP peptide (green), glycerol and Cl- ion (PDB code 4cc2)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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