Tuba
From Proteopedia
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'''Tuba''' or '''dynamin-binding protein''' is a scaffold protein found in brain synapses which brings together dynamin and actin regulatory proteins. The N-terminal SH3 domains bind dynamin and the C-terminal SH3 domain binds actin regulatory proteins<ref>PMID:14506234</ref>. | '''Tuba''' or '''dynamin-binding protein''' is a scaffold protein found in brain synapses which brings together dynamin and actin regulatory proteins. The N-terminal SH3 domains bind dynamin and the C-terminal SH3 domain binds actin regulatory proteins<ref>PMID:14506234</ref>. | ||
| + | For more details see [[Schubert lab: bacterial InIC disrupts human Tuba complexes]]. | ||
== Disease == | == Disease == | ||
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Tuba contains 6 SH3 domains. The C-terminal 6th SH3 domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues<ref>PMID:24332715</ref>. | Tuba contains 6 SH3 domains. The C-terminal 6th SH3 domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues<ref>PMID:24332715</ref>. | ||
| - | + | ==Tuba 3D structures== | |
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| + | See [[Tuba 3D structures]] | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
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