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2pc2

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(New page: 200px {{Structure |PDB= 2pc2 |SIZE=350|CAPTION= <scene name='initialview01'>2pc2</scene>, resolution 1.538&Aring; |SITE= <scene name='pdbsite=AC1:Eu+Binding+Site+...)
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[[Image:2pc2.jpg|left|200px]]
 
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{{Structure
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==Lysozyme Cocrystallized with Tris-dipicolinate Eu complex==
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|PDB= 2pc2 |SIZE=350|CAPTION= <scene name='initialview01'>2pc2</scene>, resolution 1.538&Aring;
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<StructureSection load='2pc2' size='340' side='right'caption='[[2pc2]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Eu+Binding+Site+For+Residue+A+201'>AC1</scene>, <scene name='pdbsite=AC2:Eu+Binding+Site+For+Residue+A+202'>AC2</scene>, <scene name='pdbsite=AC3:Eu+Binding+Site+For+Residue+A+203'>AC3</scene>, <scene name='pdbsite=AC4:Eu+Binding+Site+For+Residue+A+204'>AC4</scene>, <scene name='pdbsite=AC5:Eu+Binding+Site+For+Residue+A+205'>AC5</scene>, <scene name='pdbsite=AC6:Cl+Binding+Site+For+Residue+A+206'>AC6</scene>, <scene name='pdbsite=AC7:Pdc+Binding+Site+For+Residue+A+302'>AC7</scene>, <scene name='pdbsite=AC8:Pdc+Binding+Site+For+Residue+A+303'>AC8</scene>, <scene name='pdbsite=AC9:Pdc+Binding+Site+For+Residue+A+304'>AC9</scene>, <scene name='pdbsite=BC1:Pdc+Binding+Site+For+Residue+A+402'>BC1</scene>, <scene name='pdbsite=BC2:Pdc+Binding+Site+For+Residue+A+403'>BC2</scene>, <scene name='pdbsite=BC3:Pdc+Binding+Site+For+Residue+A+404'>BC3</scene>, <scene name='pdbsite=BC4:Pdc+Binding+Site+For+Residue+A+502'>BC4</scene>, <scene name='pdbsite=BC5:Pdc+Binding+Site+For+Residue+A+503'>BC5</scene>, <scene name='pdbsite=BC6:Pdc+Binding+Site+For+Residue+A+504'>BC6</scene>, <scene name='pdbsite=BC7:Pdc+Binding+Site+For+Residue+A+602'>BC7</scene>, <scene name='pdbsite=BC8:Pdc+Binding+Site+For+Residue+A+603'>BC8</scene>, <scene name='pdbsite=BC9:Pdc+Binding+Site+For+Residue+A+604'>BC9</scene> and <scene name='pdbsite=CC1:Pdc+Binding+Site+For+Residue+A+702'>CC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EU:EUROPIUM+ION'>EU</scene>, <scene name='pdbligand=PDC:PYRIDINE-2,6-DICARBOXYLIC+ACID'>PDC</scene>
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<table><tr><td colspan='2'>[[2pc2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PC2 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EU:EUROPIUM+ION'>EU</scene>, <scene name='pdbligand=PDC:PYRIDINE-2,6-DICARBOXYLIC+ACID'>PDC</scene></td></tr>
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|GENE=
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00119 LYZ1]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc2 OCA], [https://pdbe.org/2pc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pc2 RCSB], [https://www.ebi.ac.uk/pdbsum/2pc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc2 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc2 OCA], [http://www.ebi.ac.uk/pdbsum/2pc2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pc2 RCSB]</span>
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== Function ==
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}}
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[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/2pc2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pc2 ConSurf].
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<div style="clear:both"></div>
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'''Lysozyme Cocrystallized with Tris-dipicolinate Eu complex'''
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2PC2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC2 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Chick]]
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Protein Crystallography through Supramolecular Interactions between a Lanthanide Complex and Arginine., Pompidor G, D'Aleo A, Vicat J, Toupet L, Giraud N, Kahn R, Maury O, Angew Chem Int Ed Engl. 2008 Mar 18;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18350532 18350532]
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[[Category: Large Structures]]
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[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: Single protein]]
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[[Category: Kahn, R]]
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[[Category: Kahn, R.]]
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[[Category: Pompidor, G]]
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[[Category: Pompidor, G.]]
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[[Category: Vicat, J]]
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[[Category: Vicat, J.]]
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[[Category: Hydrolase]]
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[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:57:28 2008''
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Current revision

Lysozyme Cocrystallized with Tris-dipicolinate Eu complex

PDB ID 2pc2

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