This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6jcd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6jcd is ON HOLD Authors: Winnerdy, F.R., Truong, T.H.A., Phan, A.T. Description: G-quadruplex peripheral knot Category: Unreleased Structures [...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==G-quadruplex peripheral knot== | |
| + | <StructureSection load='6jcd' size='340' side='right'caption='[[6jcd]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6jcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JCD FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcd OCA], [https://pdbe.org/6jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jcd RCSB], [https://www.ebi.ac.uk/pdbsum/6jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A knot-like G-quadruplex peripheral structure is formed by a 7-nt DNA sequence DL7 (TGTTGGT), in which six out of its seven nucleobases participate in compact base-pairing interactions. Here, the solution NMR structure of a 24-nt DNA oligonucleotide containing the DL7 sequence shows the interaction between a two-layer anti-parallel G-quadruplex core and the peripheral knot-like structure, including the construction of two sharp turns in the DNA backbone. The formation of this novel structural element highlights the intricate properties of single-stranded DNA folding in presence of G-quadruplex-forming motifs. We demonstrated the compatibility of the DL7 knot-like structure with various G-quadruplexes, which could have implications in drug design and DNA engineering. | ||
| - | + | An Unprecedented Knot-like G-Quadruplex Peripheral Motif.,Truong THA, Winnerdy FR, Phan AT Angew Chem Int Ed Engl. 2019 Jul 17. doi: 10.1002/anie.201907740. PMID:31317601<ref>PMID:31317601</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6jcd" style="background-color:#fffaf0;"></div> |
| - | [[Category: Phan | + | == References == |
| - | [[Category: Winnerdy | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Phan AT]] | ||
| + | [[Category: Truong THA]] | ||
| + | [[Category: Winnerdy FR]] | ||
Current revision
G-quadruplex peripheral knot
| |||||||||||
